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논문 기본 정보

자료유형
학술저널
저자정보
Young-Min Lee (인제대학교) Oh-Cheon Gweon (경남도립남해대학) Yeong-Ju Seo (인제대학교) Jieun Im (인제대학교) Min-Jung Kang (인제대학교) Myo-Jeong Kim (인제대학교) Jung-In Kim (인제대학교)
저널정보
대한지역사회영양학회 Nutrition Research and Practice Nutrition Research and Practice Vol.3 No.2
발행연도
2009.6
수록면
156 - 161 (6page)

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Hyperglycemia in the diabetic state increases oxidative stress and antioxidant therapy can be strongly correlated with decreased risks for diabetic complications. The purpose of this study is to determine antioxidant effect of garlic and aged black garlic in animal model of type 2 diabetes. The antioxidant activity of garlic and aged black garlic was measured as the activity in scavenging free radicals by the trolox equivalent antioxidant capacity (TEAC) assay. Three week-old db/db mice were fed AIN-93G diet or diet containing 5% freeze-dried garlic or aged black garlic for 7 weeks after 1 week of adaptation. Hepatic levels of lipid peroxides and activities of antioxidant enzymes were measured. TEAC values of garlic and aged black garlic were 13.3 ± 0.5 and 59.2 ± 0.8 μ㏖/g wet weight, respectively. Consumption of aged black garlic significantly decreased hepatic thiobarbituric acid reactive substances (TBARS) level compared with the garlic group which showed lower TBARS level than control group (p<0.05). Activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) of garlic and aged black garlic group were significantly elevated compared to the control group. Catalase (CAT) activity of aged black garlic group was increased compared with the control group. These results show that aged black garlic exerts stronger antioxidant activity than garlic in vitro and in vivo, suggesting garlic and aged black garlic, to a greater extent, could be useful in preventing diabetic complications.

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Abstract
Introduction
Materials and methods
Results
Discussion
Literature cited

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