메뉴 건너뛰기
Library Notice
Institutional Access
If you certify, you can access the articles for free.
Check out your institutions.
ex)Hankuk University, Nuri Motors
Log in Register Help KOR
Subject
Humanities
General Humanities History Philosophy Religious Studies Linguistics and Literature Other Humanities
Social science
General Social Science Business Management Tourism Education Military Science Library and Information Science Law Sociology Journalism and Media Studies Psychological Science Political Science and Diplomacy Geography Public Administration Economics International Trade Anthropology Other Social Science
Natural science
General Natural Science Physics Biology Life Sciences Mathematics/Statistics Astronomy Earth Science Chemistry Other Natural Science
Engineering
General Engineering Architectural Engineering Mechanical Engineering Industrial Engineering Material/Energy Engineering Electrical and Electronic Engineering Marine and Ocean Engineering Chemical Engineering Computer Science Other Engineering
Medical science
General Medical Science Nursing Science Veterinary Pharmacy Traditional Korean Medicine Basic Medicine Clinical Medicine Other Medicine
Agriculture and Fishery
General Agriculture and Fishery Agriculture Fishery Science Food Science Forestry Animal Husbandry Marine Transportation Studies Other Agriculture and Fishery
Art and Kinesiology
General Arts Design Fine Arts Cosmetology Photography Music Fashion Kinesiology Performing Media Arts Other Arts and Kinesiology
Interdisciplinary Studies
Interdisciplinary Research Science and Technology Studies Brain and Cognitive Science Technology Policy Other Interdisciplinary Studies

KOR

In Vitro Screening for Anti-Dementia Activities of Seaweed Extracts
Recommendations
Search
Questions

해조류 추출물의 In Vitro 항치매 활성

논문 기본 정보

Type
Academic journal
Author
Hyun Jung Son (한국식품연구원) Min Young Um (한국식품연구원) Inho Kim (한국식품연구원) Suengmok Cho (한국식품연구원) Daeseok Han (한국식품연구원) Changho Lee (한국식품연구원)
Journal
The korean Society of Food Science and Nutrition Journal of the Korean Society of Food Science and Nutrition Vol.45 No.7 KCI Accredited Journals SCOPUS
Published
2016.7
Pages
966 - 972 (7page)

Usage

cover
📌
Topic
📖
Background
🔬
Method
🏆
Result
In Vitro Screening for Anti-Dementia Activities of Seaweed Extracts
Ask AI
Recommendations
Search
Questions

Abstract· Keywords

Report Errors
We investigated that methanolic extracts of 20 kinds of seaweeds from Jeju Island for their antioxidant activities, acetylcholinesterase and β-secretase inhibitory activities, and neuronal survival in order to evaluate their potentials as anti-dementia agents. Ecklonia cava extracts had the highest total polyphenol content among the 20 seaweed extracts. The antioxidant activity of seaweed extracts was measured by using 2,2"-azino-bis-(3-ethylbenzothiazoline- 6-sulfonic acid) (ABTS) assay. It was found that Ecklonia kurome extracts had the highest ABTS scavenging activity (IC<SUB>50</SUB>=0.07±0.01 mg/mL). As a result, Ecklonia cava, Ecklonia kurome, and Myelophycus simplex extracts were found to be the most effective in terms of acetylcholinesterase inhibitory activity. In the β-secretase activity assay, Ecklonia cava and Ecklonia kurome extracts were effectively inhibited (84.41±1.70% and 81.17±2.43%, respectively). As expected, neuronal cell death induced by H₂O₂ in SH-SY5Y cells was diminished by Ecklonia cava, Ecklonia kurome, and Sargassum yezoense extracts. Taken together, these results showed that Ecklonia cava extract has potential anti-dementia activity, which suggests that it might provide an effective strategy for improving dementia.
#seaweed extracts #Alzheimers disease #acetylcholinesterase #antioxidant activity #neuroprotective effect

Contents

ABSTRACT
서론
재료 및 방법
결과 및 고찰
요약
REFERENCES

References (38)

Add References
[기타자료] - KOSTAT / 2015 / Elderly statistics 2015 / Statistics Korea google schola [학술지(정기간행물)] - Morris JC / 1996 / Classification of dementia and Alzheimer's disease / Acta Neurol Scand 165 : 41 ~ 50 google schola [학술지(정기간행물)] - Selkoe DJ. / 1999 / Translating cell biology into therapeutic advances in Alzheimer's disease / Nature 399 : A23 ~ A31 google schola [학술지(정기간행물)] - Hwang DY. / 2002 / Alterations in behavior, amyloid beta-42, caspase-3, and Cox-2 in mutant PS2 transgenic mouse model of Alzheimer's disease / FASEB J 16 : 805 ~ 813 google schola [학술지(정기간행물)] - 박규환 / 2013 / 베타아밀로이드로 유도된 신경소교세포 사멸에 대한 루테올린의 보호효과 연구 / 대한본초학회지 28 (6) : 79 ~ 86 dbpia

Recommendations

It is an article recommended by DBpia according to the article similarity. Check out the related articles!

Related Authors

Frequently Viewed Together

Studies on Bioactive Substances and Antioxidant Activities of Marine Algae from Jeju Island
Tae-Hee Kim ,  Seok-Chun Ko ,  Gun-Woo Oh and others 9 Journal of Marine Bioscience and Biotechnology 2016 .06
Antioxidant Activities and Acetylcholinesterase Inhibitory Activities from Seaweed Extracts
Young Eun Jeon ,  Xing Fu Yin ,  Soon Sung Lim and others 2 Journal of the Korean Society of Food Science and Nutrition 2012 .04
Geriatric Hospital Nurses’ Empathy, Attitude and Pain Management for Patients with Dementia
Lee ,  Mihyun ,  Pa Korean Journal of Adult Nursing 2016 .08
A Study in Terms of the Establishment and Operational Method of Dementia Management System on Local Community : An Analysis of Relative Importance Using the Method of AHP (Analytic Hierarchy Process)
Kim ,  Keun Hye ,  Yun The Korean Journal of Local Government Studies 2016 .08
Ameliorating Effect of Water Extract from Dendropanax morbifera Lev. on Memory Dysfunction in Streptozotocin-induced Diabetic Rats
Ji Hye Kim ,  Dong hyuck Bae ,  Uk Lee and others 1 Korean journal of food science and technology 2016 .06

Comments(0)

0

Write first comments.

UCI(KEPA) : I410-ECN-0101-2017-594-000774852