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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 119 - 125 (7page)
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초록· 키워드
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The Hippo pathway plays prominent and widespread roles in various forms of human carcinogenesis. Specifically, the Yes-associated protein (YAP), a downstream effector of the Hippo pathway, can lead to excessive cell proliferation and the inhibition of apoptosis, resulting in tumorigenesis. It was reported that the YAP is strongly elevated in multiple types of human malignancies such as breast, lung, small intestine, colon, and liver cancers. Recent work indicates that, surprisingly, Hippo signaling components’ (SAV1, MST1/2, Lats1/2) mutations are virtually absent in human cancer, rendering this signaling an unlikely candidate to explain the vigorous activation of the YAP in most, if not all human tumors and an activated YAP promotes the resistance to RAF-, MAPK/ERK Kinase (MEK)-, and Epidermal growth factor receptor (EGFR)-targeted inhibitor therapy. The analysis of YAP expressions can facilitate the identification of patients who respond better to an anti-cancer drug treatment comprising RAF-, MEK-, and EGFR-targeted inhibitors. The prominence of YAP for those aspects of cancer biology denotes that these factors are ideal targets for the development of anti-cancer medications. Therefore, our report strongly indicates that the YAP is of potential prognostic utility and druggability in various human cancers.
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참고문헌 (94)
참고문헌 신청
Harvey K / 2007 / The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor network / Nat Rev Cancer 7:182~191
Meignin C / 2007 / The salvador-warts-hippo pathway is required for epithelial proliferation and axis specification in Drosophila / Curr Biol 17:1871~1878
Zhang X / 2009 / Transcriptional output of the Salvador/warts/hippo pathway is controlled in distinct fashions in Drosophila melanogaster and mammalian cell lines / Cancer Res 69:6033~6041
Huang J / 2005 / The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP / Cell 122:421~434
Kango-Singh M / 2009 / Singh, Regulation of organ size: insights from the Drosophila Hippo signaling pathway / Dev Dyn 238:1627~1637
Meignin C / 2007 / The salvador-warts-hippo pathway is required for epithelial proliferation and axis specification in Drosophila / Curr Biol 17:1871~1878
Zhang X / 2009 / Transcriptional output of the Salvador/warts/hippo pathway is controlled in distinct fashions in Drosophila melanogaster and mammalian cell lines / Cancer Res 69:6033~6041
Huang J / 2005 / The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP / Cell 122:421~434
Kango-Singh M / 2009 / Singh, Regulation of organ size: insights from the Drosophila Hippo signaling pathway / Dev Dyn 238:1627~1637
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Overcoming BRAF and CDK4/6 inhibitor resistance by inhibiting MAP3K3-dependent protection against YAP lysosomal degradation
Experimental and Molecular Medicine
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The potential role of YAP in head and neck squamous cell carcinoma
Experimental and Molecular Medicine
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Regulation of Hippo signaling by actin remodeling
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Dishevelling Wnt and Hippo
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Regulation and Regulators of the Hippo-YAP/TAZ Pathway
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DNA binding partners of YAP/TAZ
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2018 .01
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Resveratrol suppresses breast cancer cell invasion by inactivating a RhoA/YAP signaling axis
Experimental and Molecular Medicine
2017 .01
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The role of extracellular biophysical cues in modulating the Hippo-YAP pathway
BMB Reports
2017 .01
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Roles of YAP in mediating endothelial cell junctional stability and vascular remodeling
BMB Reports
2015 .01
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YAP inactivation in estrogen receptor alpha-positive hepatocellular carcinoma with less aggressive behavior
Experimental and Molecular Medicine
2021 .06
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Hippo-YAP/TAZ signaling in angiogenesis
BMB Reports
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Deubiquitinase YOD1: the potent activator of YAP in hepatomegaly and liver cancer
BMB Reports
2017 .06
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Insulin receptor substrate 2: a bridge between Hippo and AKT pathways
BMB Reports
2018 .01
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YAP1 inhibits the senescence of alveolar epithelial cells by targeting Prdx3 to alleviate pulmonary fibrosis
Experimental and Molecular Medicine
2024 .07
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Interacting network of Hippo, Wnt/β-catenin and Notch signaling represses liver tumor formation
BMB Reports
2017 .01
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Regulation of the Hippo signaling pathway by ubiquitin modification
BMB Reports
2018 .01
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Effect of PFKFB3 on YAP-TEAD Interaction
한국생물공학회 학술대회
2024 .09
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The history and regulatory mechanism of the Hippo pathway
BMB Reports
2018 .01
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A novel role of Hippo-Yap/TAZ signaling pathway in lymphatic vascular development
BMB Reports
2021 .01
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