지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 1 - 9 (9page)
이용수
이 논문의 연구 히스토리 (2)
2017
Resveratrol이 유방암세포의 Hippo-YAP에 의한 침윤 억제에 미치는 영향 : Resveratrol suppresses breast cancer cell invasion by inactivating a RhoA/YAP signaling axis
김유나
의학과
2017.01
학위논문
Resveratrol suppresses breast cancer cell invasion by inactivating a RhoA/YAP signaling axis
김유나
,
최소라
,
조경화
외 4명
Experimental and Molecular Medicine
2017.01
학술저널
- 이 논문의 후속연구가 궁금하신가요?
- 연관 학술논문 또는 학술발표를 통해 보다 발전된 연구결과를 확인하실 수 있습니다.
- 이 논문의 연구 히스토리 확인하기
초록· 키워드
오류제보하기
Hippo/YAP signaling is implicated in tumorigenesis and progression of various cancers. By inhibiting a plethora signaling cascades, resveratrol has strong anti-tumorigenic and anti-metastatic activity. In the present study, we demonstrate that resveratrol decreases the expression of YAP target genes. In addition, our data showed that resveratrol attenuates breast cancer cell invasion through the activation of Lats1 and consequent inactivation of YAP. Strikingly, we also demonstrate that resveratrol inactivates RhoA, leading to the activation of Lats1 and induction of YAP phosphorylation. Further, resveratrol in combination with other agents that inactivate RhoA or YAP showed more marked suppression of breast cancer cell invasion compared with single treatment. Collectively, these findings indicate the beneficial effects of resveratrol on breast cancer patients by suppressing the RhoA/Lats1/YAP signaling axis and subsequently inhibiting breast cancer cell invasion.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Burns J / 2002 / Plant foods and herbal sources of resveratrol / J Agric Food Chem 50 : 3337 ~ 3340
Chin YT / 2014 / Anti-proliferative and gene expression actions of resveratrol in breast cancer cells in vitro / Oncotarget 5 : 12891 ~ 12907
Choi MJ / 2015 / hTERT mediates norepinephrine-induced Slug expression and ovarian cancer aggressiveness / Oncogene 34 : 3402 ~ 3412
Cordenonsi M / 2011 / The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells / Cell 147 : 759 ~ 772
Dong J / 2007 / Elucidation of a universal size-control mechanism in Drosophila and mammals / Cell 130 : 1120 ~ 1133
Chin YT / 2014 / Anti-proliferative and gene expression actions of resveratrol in breast cancer cells in vitro / Oncotarget 5 : 12891 ~ 12907
Choi MJ / 2015 / hTERT mediates norepinephrine-induced Slug expression and ovarian cancer aggressiveness / Oncogene 34 : 3402 ~ 3412
Cordenonsi M / 2011 / The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells / Cell 147 : 759 ~ 772
Dong J / 2007 / Elucidation of a universal size-control mechanism in Drosophila and mammals / Cell 130 : 1120 ~ 1133
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Clinical implications of the Hippo-YAP pathway in multiple cancer contexts
BMB Reports
2018 .01
-
Overcoming BRAF and CDK4/6 inhibitor resistance by inhibiting MAP3K3-dependent protection against YAP lysosomal degradation
Experimental and Molecular Medicine
2024 .04
-
The potential role of YAP in head and neck squamous cell carcinoma
Experimental and Molecular Medicine
2020 .08
-
YAP inactivation in estrogen receptor alpha-positive hepatocellular carcinoma with less aggressive behavior
Experimental and Molecular Medicine
2021 .06
-
DNA binding partners of YAP/TAZ
BMB Reports
2018 .01
-
Roles of YAP in mediating endothelial cell junctional stability and vascular remodeling
BMB Reports
2015 .01
-
Regulation of Hippo signaling by actin remodeling
BMB Reports
2018 .01
-
Dishevelling Wnt and Hippo
BMB Reports
2018 .01
-
유방암세포 성장과 Bmi-1 발현에 대한 레스베라트롤의 억제 효과
KSBB Journal
2017 .09
-
YAP1 inhibits the senescence of alveolar epithelial cells by targeting Prdx3 to alleviate pulmonary fibrosis
Experimental and Molecular Medicine
2024 .07
-
Hippo-YAP/TAZ signaling in angiogenesis
BMB Reports
2018 .01
-
Zeb1 for RCP-induced oral cancer cell invasion and its suppression by resveratrol
Experimental and Molecular Medicine
2020 .01
-
Deubiquitinase YOD1: the potent activator of YAP in hepatomegaly and liver cancer
BMB Reports
2017 .06
-
Regulation and Regulators of the Hippo-YAP/TAZ Pathway
한국생물공학회 학술대회
2016 .10
-
The role of extracellular biophysical cues in modulating the Hippo-YAP pathway
BMB Reports
2017 .01
-
Effect of PFKFB3 on YAP-TEAD Interaction
한국생물공학회 학술대회
2024 .09
-
Gastrin stimulates pancreatic cancer cell directional migration by activating the Gα12/13–RhoA–ROCK signaling pathway
Experimental and Molecular Medicine
2018 .01
-
Insulin receptor substrate 2: a bridge between Hippo and AKT pathways
BMB Reports
2018 .01
-
The Foxo1-YAP-Notch1 axis reprograms STING-mediated innate immunity in NASH progression
Experimental and Molecular Medicine
2024 .08
-
Interacting network of Hippo, Wnt/β-catenin and Notch signaling represses liver tumor formation
BMB Reports
2017 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0