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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 157 - 162 (6page)
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Angiogenesis is a complex, multistep process involving dynamic changes in endothelial cell (EC) shapes and behaviors, especially in specialized cell types such as tip cells (with active filopodial extensions), stalk cells (with less motility) and phalanx cells (with stable junction connections). The Hippo-Yes-associated protein (YAP)/ transcription activator with PDZ binding motif (TAZ) signaling plays a critical role in development, regeneration and organ size by regulating cell-cell contact and actin cytoskeleton dynamics. Recently, with the finding that YAP is expressed in the front edge of the developing retinal vessels, Hippo-YAP/TAZ signaling has emerged as a new pathway for blood vessel development. Intriguingly, the LATS1/2-mediated angiomotin (AMOT) family and YAP/TAZ activities contribute to EC shapes and behaviors by spatiotemporally modulating actin cytoskeleton dynamics and EC junction stability. Herein, we summarize the recent understanding of the role of Hippo-YAP/TAZ signaling in the processes of EC sprouting and junction maturation in angiogenesis.
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참고문헌 (49)
참고문헌 신청
Herbert SP / 2011 / Molecular control of endothelial cell behaviour during blood vessel morphogenesis / Nat Rev Mol Cell Biol 12:551~564
Potente M / 2005 / Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization / J Clin Invest 115:2382~2392
Birdsey GM / 2008 / Transcription factor Erg regulates angiogenesis and endothelial apoptosis through VE-cadherin / Blood 111:3498~3506
Felcht M / 2012 / Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling / J Clin Invest 122:1991~2005
Nakayama M / 2013 / Spatial regulation of VEGF receptor endocytosis in angiogenesis / Nat Cell Biol 15:249~260
Potente M / 2005 / Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization / J Clin Invest 115:2382~2392
Birdsey GM / 2008 / Transcription factor Erg regulates angiogenesis and endothelial apoptosis through VE-cadherin / Blood 111:3498~3506
Felcht M / 2012 / Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling / J Clin Invest 122:1991~2005
Nakayama M / 2013 / Spatial regulation of VEGF receptor endocytosis in angiogenesis / Nat Cell Biol 15:249~260
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