지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.8
- 수록면
- 1 - 11 (11page)
- DOI
- 10.1038/s12276-020-00492-9
이용수
초록· 키워드
오류제보하기
The transcriptional cofactor YAP and its inhibitory regulators, Hippo kinases and adapter proteins, constitute an evolutionarily conserved signaling pathway that controls organ size and cell fate. The activity of the Hippo-YAP pathway is determined by a variety of intracellular and intercellular cues, such as cell polarity, junctions, density, mechanical stress, energy status, and growth factor signaling. Recent studies have demonstrated that YAP can induce the expression of a set of genes that allow cancer cells to gain a survival advantage and aggressive behavior. Comprehensive genomic studies have revealed frequent focal amplifications of the YAP locus in human carcinomas, including head and neck squamous cell carcinoma (HNSCC). Moreover, FAT1, which encodes an upstream component of Hippo signaling, is one of the most commonly altered genes in HNSCC. In this review, we discuss the causes and functional consequences of YAP dysregulation in HNSCC. We also address interactions between YAP and other oncogenic drivers of HNSCC.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Clinical implications of the Hippo-YAP pathway in multiple cancer contexts
BMB Reports
2018 .01
-
Regulation of Hippo signaling by actin remodeling
BMB Reports
2018 .01
-
Overcoming BRAF and CDK4/6 inhibitor resistance by inhibiting MAP3K3-dependent protection against YAP lysosomal degradation
Experimental and Molecular Medicine
2024 .04
-
Roles of YAP in mediating endothelial cell junctional stability and vascular remodeling
BMB Reports
2015 .01
-
Dishevelling Wnt and Hippo
BMB Reports
2018 .01
-
DNA binding partners of YAP/TAZ
BMB Reports
2018 .01
-
Hippo-YAP/TAZ signaling in angiogenesis
BMB Reports
2018 .01
-
YAP inactivation in estrogen receptor alpha-positive hepatocellular carcinoma with less aggressive behavior
Experimental and Molecular Medicine
2021 .06
-
Regulation and Regulators of the Hippo-YAP/TAZ Pathway
한국생물공학회 학술대회
2016 .10
-
The role of extracellular biophysical cues in modulating the Hippo-YAP pathway
BMB Reports
2017 .01
-
Resveratrol suppresses breast cancer cell invasion by inactivating a RhoA/YAP signaling axis
Experimental and Molecular Medicine
2017 .01
-
YAP1 inhibits the senescence of alveolar epithelial cells by targeting Prdx3 to alleviate pulmonary fibrosis
Experimental and Molecular Medicine
2024 .07
-
Deubiquitinase YOD1: the potent activator of YAP in hepatomegaly and liver cancer
BMB Reports
2017 .06
-
Effect of PFKFB3 on YAP-TEAD Interaction
한국생물공학회 학술대회
2024 .09
-
Interacting network of Hippo, Wnt/β-catenin and Notch signaling represses liver tumor formation
BMB Reports
2017 .01
-
The history and regulatory mechanism of the Hippo pathway
BMB Reports
2018 .01
-
Regulation of the Hippo signaling pathway by ubiquitin modification
BMB Reports
2018 .01
-
Insulin receptor substrate 2: a bridge between Hippo and AKT pathways
BMB Reports
2018 .01
-
A novel role of Hippo-Yap/TAZ signaling pathway in lymphatic vascular development
BMB Reports
2021 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0