Lack of Any Role of Systemic Inflammatory Responses in Predicting Muscle Invasion by Bladder Cancer

Solakhan, Mehmet; Demirpence, Ozlem; Orhan, Nuri; Yildirim, Omer Aydin; Guzel, Ebru; Yildirim, Mustafa

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자료유형: 학술저널

저자정보: Solakhan, Mehmet (Department of Urology, Medicalpark Gaziantep Hospital) Demirpence, Ozlem (Department of Bioichemistry, Cumhuriyet University) Orhan, Nuri (Department of Biochemistry, Medicalpark Gaziantep Hospital) Yildirim, Omer Aydin (Department of Internal Medicine, Medicalpark Gaziantep Hospital) Guzel, Ebru (Department of Radiology, Medicalpark Gaziantep Hospital) Yildirim, Mustafa (Department of Medical Oncology, Medicalpark Gaziantep Hospital)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제17권 제8호

발행연도: 2016.1

수록면: 3,735 - 3,737 (3page)

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Background: The purpose of this study is to evaluate if there is a relation between platelet: lymphocyte ratio (PLR) and neutrophil lymphocyte ratio (NLR) values and tumour histology and spread in bladder cancer cases. Materials and Methods: Bladder cancer patients undergoing TUR-M operation, with histopathologically verified diagnosis, followed-up and treated at the Private Medical Park Gaziantep Hospital between 2010 and 2015, have were included in the study. NLR and PLR values were calculated using complete blood count data obtained at the first presentation. Results: A total of 99 patients were included in the study, 7 (7.1%) women and 92 men (92.9%). When NLR was used as the indicator of systemic inflammatory response (SIR), it was determined that, 52 (52.5%) of the patients were SIR negative and 47 (47.5%) SIR positive. No significant relation could be detected between NLR and tumour grade and muscle invasion (p=0.948, p=0.480). When PLR was used as SIR indicator, it was determined that 71 (71.7%) of the patients were found as negative and 28 (28.3%) as positive. No significant relation could be detected between PLR and tumour grade and muscle invasion (p=0.651, p=0.494). Conclusions: In our study we did not detected a relation between tumour histological behavior and PLR and NLR in bladder cancer. However, NLR and PLR are easily calculated, accessible, inexpensive and simple-to-use laboratory data from whole blood counts.

#Neutrophil/lymphocyte ratio #platelet/lymphocyte ratio #bladder cancer #prognosis #muscle invasion

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