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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 383 - 388 (6page)
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Purpose: To estimate long-term outcomes after treatment modification in patients with chronic hepatitis B (CHB) treated withentecavir (ETV) and telbivudine (LdT). Materials and Methods: The study enrolled 131 nucleos(t)ide analogue (NA)-naïve CHB patients treated with ETV or LdT. Duringthe 3-year study, NA treatment history including the incidence, the type of treatment modification, reasons for the modification,and overall complete virologic response (CVR) rate were retrospectively evaluated using the patients’ medical records. Results: Among the 131 patients, 84 and 47 were initially treated with ETV and LdT, respectively. During the course of 3-yearstudy, 82 patients in the ETV group (97.6%) maintained initial treatment whereas only 19 in the LdT group (40.4%). In the LdTgroup, 26 patients (92.9%) switched to another NA and another NA was added in 2 (7.1%) patients. An assessment of the CVR rateat 3 years, including treatment modification, showed that 89.3% and 95.7% of patients in the ETV and LdT groups, respectively,had undetectable serum hepatitis B virus DNA levels (p=0.329). Among LdT patients with treatment modification, the cumulativeincidence rate of a CVR for rescue therapy was significantly higher in the tenofovir than in the ETV group (p=0.009). Conclusion: During the 3-year study, there were no significant differences in the CVR between the ETV and LdT groups if appropriaterescue therapy was considered.
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참고문헌 (21)
참고문헌 신청
Buti M / 2015 / Seven-year efficacy and safety of treatment with tenofovir disoproxil fumarate for chronic hepatitis B virus infection / Dig Dis Sci 60:1457~1464
Idilman R / 2015 / Long-term entecavir or tenofovir disoproxil fumarate therapy in treatment-naive chronic hepatitis B patients in the real-world setting / J Viral Hepat 22:504~510
Lampertico P / 2016 / Review article: long-term safety of nucleoside and nucleotide analogues in HBV-monoinfected patients / Aliment Pharmacol Ther 44:16~34
Zeuzem S / 2009 / Baseline characteristics and early on-treatment response predict the outcomes of 2 years of telbivudine treatment of chronic hepatitis B / J Hepatol 51:11~20
Wang Y / 2013 / Efficacy and safety of continuous 4-year telbivudine treatment in patients with chronic hepatitis B / J Viral Hepat 20:e37~e46
Idilman R / 2015 / Long-term entecavir or tenofovir disoproxil fumarate therapy in treatment-naive chronic hepatitis B patients in the real-world setting / J Viral Hepat 22:504~510
Lampertico P / 2016 / Review article: long-term safety of nucleoside and nucleotide analogues in HBV-monoinfected patients / Aliment Pharmacol Ther 44:16~34
Zeuzem S / 2009 / Baseline characteristics and early on-treatment response predict the outcomes of 2 years of telbivudine treatment of chronic hepatitis B / J Hepatol 51:11~20
Wang Y / 2013 / Efficacy and safety of continuous 4-year telbivudine treatment in patients with chronic hepatitis B / J Viral Hepat 20:e37~e46
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