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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 323 - 330 (8page)
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Background/Aims: Clinical characteristics of patients with chronic hepatitis B (CHB) who developed genotypic resistance to entecavir (ETV) were compared to those without resistance.
Methods: Two hundred fifty eight CHB patients who underwent ETV treatment in our institution from July 2007 to May 2013 were included.
Results: Eight (3.1%) patients developed genotypic resistance to ETV during the follow-up period. The patterns of genotypic resistance to ETV were as follows: L180M + M204V + S202G (n=3); M204I + V173M (n=1); I169V + V173M (n=1); L180M + M204V + V173L (n=1); L180M + M204V + V173L + M250V (n=1); M204I + V214A + P237H (n=1). The cumulative occurrence rates of genotypic resistance to ETV were not significantly different between CHB patients with prior nucleos(t)tide analogues (NA) exposure (NA experienced, n=56) and NA naïve patients (n=202, P=0.823 by log rank comparison). Older age, higher baseline log10hepatitis B virus-deoxynucleic acid (log10HBV-DNA), higher log10HBV-DNA at 3, 6, 12 and 24 months after baseline, and complete virologic response (CVR, undetectable serum HBV-DNA by polymerase chain reaction 6 months after ETV treatment) were significant contributors to the development of genotypic resistance to ETV. Multivariate analyses showed higher log10HBV-DNA 6 months after baseline and absence of CVR were independent and significant contributors to the development of ETV resistance.
Conclusions: Clinical characteristics of patients who developed ETV resistance were higher log10HBV-DNA 6 months after baseline and absence of CVR during the ETV treatment.
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등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Bang SJ / 2013 / Clinical course of patients with insufficient viral suppression during entecavir therapy in genotype C chronic hepatitis B / Dig Liver Dis 45 : 600 ~ 605
Colonno RJ / 2006 / Entecavir resistance is rare in nucleoside naive patients with hepatitis B / Hepatology 44 : 1656 ~ 1665
European Association For The Study Of The Liver / 2009 / EASL Clinical Practice Guidelines: management of chronic hepatitis B / J Hepatol 50 : 227 ~ 242
Hoofnagle JH / 2007 / Management of hepatitis B: summary of a clinical research workshop / Hepatology 45 : 1056 ~ 1075
Keeffe EB / 2004 / A treatment algorithm for the management of chronic hepatitis B virus infection in the United States / Clin Gastroenterol Hepatol 2 : 87 ~ 106
Colonno RJ / 2006 / Entecavir resistance is rare in nucleoside naive patients with hepatitis B / Hepatology 44 : 1656 ~ 1665
European Association For The Study Of The Liver / 2009 / EASL Clinical Practice Guidelines: management of chronic hepatitis B / J Hepatol 50 : 227 ~ 242
Hoofnagle JH / 2007 / Management of hepatitis B: summary of a clinical research workshop / Hepatology 45 : 1056 ~ 1075
Keeffe EB / 2004 / A treatment algorithm for the management of chronic hepatitis B virus infection in the United States / Clin Gastroenterol Hepatol 2 : 87 ~ 106
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