지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1,492 - 1,496 (5page)
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초록· 키워드
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Purpose: To predict the malignant potential of prostate cancer (PCa) according to prostate-specific antigen velocity (PSAV), PSA density (PSAD), free/total PSA ratio (%fPSA), and digital rectal examination (DRE).
Materials and Methods: From January 2009 to December 2012, 548 adult male patients were diagnosed with PCa by prostate biopsyat four hospitals in Korea. We retrospectively analyzed 155 adult male patients with an initial PSA level ≤10 ng/mL and whose PSA levels had been checked more than two times at least 6 months before they had been diagnosed with PCa, with test intervals of more than 3 months. Patients with a urinary tract infection, and patients who had previously undergone cystoscopy or surgery of the prostate were excluded. We separated patients into two groups according to Gleason sum [Gleason sum ≤7 (n=134) or Gleason sum ≥8 (n=21)] and the presence of extracapsular invasion [organ confined (n=129) or extracapsular invasion (n=26)]. Differences between the groups were compared.
Results: The group with a Gleason sum ≥8 or extracapsular invasion of PCa showed high PSAV and significantly lower %fPSA. There were no significant differences in PSAD and the presence of an abnormality on DRE between two groups.
Conclusion: In PCa patients treated with other therapies besides prostatectomy, a high PSA velocity and a low %fPSA may predict high grade PCa with a Gleason sum ≥8 or the presence of extracapsular invasion.
목차
등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
Kassouf W / 2007 / Effect of prostate volume on tumor grade in patients undergoing radical prostatectomy in the era of extended prostatic biopsies / J Urol 178:111~114
Thompson IM / 2003 / The influence of finasteride on the development of prostate cancer / N Engl J Med 349:215~224
McKenney JK / 2011 / The potential impact of reproducibility of Gleason grading in men with early stage prostate cancer managed by active surveillance:a multi-institutional study / J Urol 186:465~469
Djavan B / 2002 / Repeat prostate biopsy: who, how and when?. a review / Eur Urol 42:93~103
Anast JW / 2004 / Relating biopsy and clinical variables to radical prostatectomy findings: can insignificant and advanced prostate cancer be predicted in a screening populat
Thompson IM / 2003 / The influence of finasteride on the development of prostate cancer / N Engl J Med 349:215~224
McKenney JK / 2011 / The potential impact of reproducibility of Gleason grading in men with early stage prostate cancer managed by active surveillance:a multi-institutional study / J Urol 186:465~469
Djavan B / 2002 / Repeat prostate biopsy: who, how and when?. a review / Eur Urol 42:93~103
Anast JW / 2004 / Relating biopsy and clinical variables to radical prostatectomy findings: can insignificant and advanced prostate cancer be predicted in a screening populat
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Diagnostic Role of Serum Free-to-Total Prostate Specific Antigen (PSA) Ratio in Prostate Cancer with Serum Total Concentration of PSA below 4 ng/mL
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Two-dimensional neovascular complexity is significantly higher in nontumor prostate tissue than in low-risk prostate cancer
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Comparison of the Formula of PSA, Age, Prostate Volume and Race Versus PSA Density and the Detection of Primary Malignant Circulating Prostate Cells in Predicting a Positive Initial Prostate Biopsy in Chilean Men with Suspicion of Prostate Cancer
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전립선의 염증반응과 전립선특이항원의 변화
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Correlation between Gleason score distribution and Prostate Health Index in patients with prostate-specific antigen values of 2.5–10 ng/mL
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Influence of repeated prostate-specific antigen screening on treatment pattern in a country with a limited social perception of prostate cancer: Korean national wide observational study
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Exponential Rise in Prostate-Specific Antigen (PSA) during Anti-Androgen Withdrawal Predicts PSA Flare after Docetaxel Chemotherapy in Patients with Castration-Resistant Prostate Cancer
Yonsei Medical Journal
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Pathological upgrading in prostate cancer patients eligible for active surveillance: Does prostate-specific antigen density matter?
Investigative and Clinical Urology
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전립샘 특이항원을 이용한 국가암 선별 검사의 당위성
대한의사협회지
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US Preventive Services Task Force prostate-specific antigen screening guidelines result in higher Gleason score diagnoses
Investigative and Clinical Urology
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Multicenter Comparison of Four Automated Immunoassay Analyzers for Prostate Specific Antigen
Annals of Laboratory Medicine
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