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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 86 - 91 (6page)
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초록· 키워드
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배경: PANA RealTyper HPV kit (PANAGENE, Korea; PANA RealTyper)는 multiplex real-time PCR과 melting curve analysis를 이용하여 human papillomavirus (HPV)의 유전자형을 검출한다. 본 연구에서는 PANA Real Typer와 AdvanSure HPV GenoBlot assay (LG Life Sciences, Korea; AdvanSure assay)를 비교하였다. 방법: 자궁경부암 검진을 받은 환자에서 채취한 검체를 60개 수집하였다. AdvanSure assay와 PANA RealTyper는 고위험군 HPV 20종을 검출할 수 있다. 저위험군 HPV의 경우 AdvanSure assay는 15종을, PANA RealTyper는 2종의 유전자형을 구별할 수 있고 18종의 유전자형을 검출할 수 있다. 결과: 총 60개 중 40개 검체에서 54개의 고위험군 유전자형이 검출되었으며 18개 검체에서 20개의 저위험군 유전자형이 검출되었다. 고위험군에서 두 방법 간 일치율은 94.4-100%였다. PANA Real Typer에서만 양성으로 검출된 9개 유전자형 중 7개(HPV 16 (n=1), 39 (n=1), 52 (n=1), 58 (n=2), 68 (n=2))은 진양성으로 판별되었다. AdvanSure assay에서만 양성으로 나온 4개 유전자형 중 3개는 HPV 59였다. 저위험군에서 AdvanSure assay에서 검출된 19개 유전자형 중 HPV 6 2개, HPV 11 1개였다. HPV 6 중 한 개는 PANA RealTyper에서만 양성이었다. 결론: PANA RealTyper는 AdvanSure assay와 동등한 검출력을 보였으며, 임상 검사실에서 HPV 유전자형 검사에 유용하게 쓰일 수 있을 것으로 생각한다. [Ann Clin Microbiol 2018;21:86-91]
목차
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참고문헌 (12)
참고문헌 신청
Burd EM / 2003 / Human papillomavirus and cervical cancer / Clin Microbiol Rev 16:1~17
Koliopoulos G / 2017 / Cytology versus HPV testing for cervical cancer screening in the general population / Cochrane Database Syst Rev 8:CD008587
You W / 2018 / Epidemiological study of high-risk human papillomavirus infection in subjects with abnormal cytological findings in cervical cancer screening / Exp Ther Med 15:412~418
Lagheden C / 2018 / Nationwide comprehensive human papillomavirus (HPV) genotyping of invasive cervical cancer / Br J Cancer 118:1377~1381
Kaur P / 2014 / Prevalence and clinical utility of human papilloma virus genotyping in patients with cervical lesions / J Obstet Gynaecol India 64:279~283
Koliopoulos G / 2017 / Cytology versus HPV testing for cervical cancer screening in the general population / Cochrane Database Syst Rev 8:CD008587
You W / 2018 / Epidemiological study of high-risk human papillomavirus infection in subjects with abnormal cytological findings in cervical cancer screening / Exp Ther Med 15:412~418
Lagheden C / 2018 / Nationwide comprehensive human papillomavirus (HPV) genotyping of invasive cervical cancer / Br J Cancer 118:1377~1381
Kaur P / 2014 / Prevalence and clinical utility of human papilloma virus genotyping in patients with cervical lesions / J Obstet Gynaecol India 64:279~283
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