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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 320 - 325 (6page)
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초록· 키워드
오류제보하기
Hepatitis E virus (HEV) infection accounts for 20 million annual infections worldwide. HEV can be fatal in approximately 20−30% of pregnant women. HEV infections are normally self-limiting and mostly asymptomatic. However, in patients with insufficient immunity, such as acquired immunodeficiency syndrome patients, chronic and often fatal infections may ensue. Therefore, it is likely that host immune responses, especially interferon responses, play a critical role in HEV infection control. Here, we report that an HEVencoded non-structural protein down-regulates type I interferon response. In addition, some other immune genes involved in the induction of type I interferon may be regulated as well. Detailed molecular mechanisms are currently being studied.
목차
등록된 정보가 없습니다.
참고문헌 (40)
참고문헌 신청
Forni D / 2018 / Origin and dispersal of Hepatitis E virus / Emerg. Microbes. Infect 7:11
Tam AW / 1991 / Hepatitis E virus (HEV): molecular cloning and sequencing of the full-length viral genome / Virology 185:120~131
강상민 / 2018 / Hepatitis E Virus Methyltransferase Inhibits Type I Interferon Induction by Targeting RIG-I / Journal of Microbiology and Biotechnology 28(9):1554~1562
강상민 / 2017 / Host Innate Immunity against Hepatitis E Virus and Viral Evasion Mechanisms / Journal of Microbiology and Biotechnology 27(10):1727~1735
Nari Kim / 2016 / Multilayered regulations of RIG-I in the anti-viral signaling pathway / The Journal of Microbiology 54(9):583~587
Tam AW / 1991 / Hepatitis E virus (HEV): molecular cloning and sequencing of the full-length viral genome / Virology 185:120~131
강상민 / 2018 / Hepatitis E Virus Methyltransferase Inhibits Type I Interferon Induction by Targeting RIG-I / Journal of Microbiology and Biotechnology 28(9):1554~1562
강상민 / 2017 / Host Innate Immunity against Hepatitis E Virus and Viral Evasion Mechanisms / Journal of Microbiology and Biotechnology 27(10):1727~1735
Nari Kim / 2016 / Multilayered regulations of RIG-I in the anti-viral signaling pathway / The Journal of Microbiology 54(9):583~587
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Dose-Dependent Inhibition of Melanoma Differentiation-Associated Gene 5-Mediated Activation of Type I Interferon Responses by Methyltransferase of Hepatitis E Virus
Journal of Microbiology and Biotechnology
2019 .01
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Hepatitis E Virus Papain-Like Cysteine Protease Inhibits Type I Interferon Induction by Down-Regulating Melanoma Differentiation-Associated Gene 5
Journal of Microbiology and Biotechnology
2018 .01
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Host Innate Immunity against Hepatitis E Virus and Viral Evasion Mechanisms
Journal of Microbiology and Biotechnology
2017 .01
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Hepatitis E Virus Methyltransferase Inhibits Type I Interferon Induction by Targeting RIG-I
Journal of Microbiology and Biotechnology
2018 .01
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Identification of Hepatitis E Virus in Bovine and Porcine Raw Livers
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Specific Expression of Interferon-γ Induced by Synergistic Activation Mediator-Derived Systems Activates Innate Immunity and Inhibits Tumorigenesis
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Experimental Infection of Hepatitis E Virus in Animal Models
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