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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제11호
- 발행연도
- 2018.1
- 수록면
- 1,908 - 1,915 (8page)
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초록· 키워드
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Upon viral infection, the host cell recognizes the invasion through a number of pattern recognition receptors. Melanoma differentiation associated gene 5 (MDA5) and retinoic acidinducible gene-I (RIG-I) recognize RNA molecules derived from invading viruses, activating down-stream signaling cascades, culminating in the induction of the type I interferon. On the other hand, viruses have evolved to evade type I interferon-mediated inhibition. Hepatitis E virus has been shown to encode a few antagonists of type I interferon and it is not surprising that viruses encode multiple mechanisms of viral evasion. In the present study, we demonstrated that HEV PCP strongly down-regulates MDA5-mediated activation of interferon β induction in a dose-dependent manner. Interestingly, MDA5 protein expression was almost completely abolished. In addition, polyinosinic polycytidylic acid (poly(I:C))- and Sendai virus-mediated activation of type I interferon responses were similarly abrogated in the presence of HEV PCP. Furthermore, HEV PCP down-regulates several molecules that play critical roles in the induction of type I IFN expression. Taken together, these data collectively suggest that HEV-encoded PCP is a strong antagonist of type I interferon.
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등록된 정보가 없습니다.
참고문헌 (50)
참고문헌 신청
Forni D / 2018 / Origin and dispersal of Hepatitis E virus / Emerg. Microbes Infect 7:11
Tam AW / 1991 / Hepatitis E virus(HEV) : molecular cloning and sequencing of the full-length viral genome / Virology 185:120~131
강상민 / 2017 / Host Innate Immunity against Hepatitis E Virus and Viral Evasion Mechanisms / Journal of Microbiology and Biotechnology 27(10):1727~1735
Kumar S / 2013 / Hepatitis E virus: the current scenario / Int. J. Infect. Dis 17:e228~e233
Krawczynski K / 1993 / Hepatitis E / Hepatology 17:932~941
Tam AW / 1991 / Hepatitis E virus(HEV) : molecular cloning and sequencing of the full-length viral genome / Virology 185:120~131
강상민 / 2017 / Host Innate Immunity against Hepatitis E Virus and Viral Evasion Mechanisms / Journal of Microbiology and Biotechnology 27(10):1727~1735
Kumar S / 2013 / Hepatitis E virus: the current scenario / Int. J. Infect. Dis 17:e228~e233
Krawczynski K / 1993 / Hepatitis E / Hepatology 17:932~941
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Hepatitis E Virus Methyltransferase Inhibits Type I Interferon Induction by Targeting RIG-I
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