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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제9호
- 발행연도
- 2018.1
- 수록면
- 1,554 - 1,562 (9page)
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The type I interferons (IFNs) play a vital role in activation of innate immunity in response to viral infection. Accordingly, viruses have evolved to employ various survival strategies to evade innate immune responses induced by type I IFNs. For example, hepatitis E virus (HEV) encoded papain-like cysteine protease (PCP) has been shown to inhibit IFN activation signaling by suppressing K63-linked de-ubiquitination of retinoic acid-inducible gene I (RIG-I) and TANK-binding kinase 1 (TBK1), thus effectively inhibiting down-stream activation of IFN signaling. In the present study, we demonstrated that HEV inhibits polyinosinic-polycytidylic acid (poly(I:C))-induced IFN-β transcriptional induction. Moreover, by using reporter assay with individual HEV-encoded gene, we showed that HEV methyltransferase (MeT), a nonstructural protein, significantly decreases RIG-I-induced IFN-β induction and NF-κB signaling activities in a dose-dependent manner. Taken together, we report here that MeT, along with PCP, is responsible for the inhibition of RIG-I-induced activation of type I IFNs, expanding the list of HEV-encoded antagonists of the host innate immunity.
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참고문헌 (92)
참고문헌 신청
Aggarwal R / 2009 / Epidemiology of hepatitis E: current status / J. Gastroenterol. Hepatol. 24:1484~1493
Arankalle VA / 2006 / Type-IV Indian swine HEV infects rhesus monkeys / J. Viral Hepat. 13:742~745
Teshale EH / 2010 / The two faces of hepatitis E virus / Clin. Infect. Dis. 51:328~334
Naik SR / 1992 / A large waterborne viral hepatitis E epidemic in Kanpur, India / Bull. World Health Organ. 70:597~604
Ricci A / 2017 / Public health risks associated with hepatitis E virus (HEV) as a food-borne pathogen / EFSA J. 15
Arankalle VA / 2006 / Type-IV Indian swine HEV infects rhesus monkeys / J. Viral Hepat. 13:742~745
Teshale EH / 2010 / The two faces of hepatitis E virus / Clin. Infect. Dis. 51:328~334
Naik SR / 1992 / A large waterborne viral hepatitis E epidemic in Kanpur, India / Bull. World Health Organ. 70:597~604
Ricci A / 2017 / Public health risks associated with hepatitis E virus (HEV) as a food-borne pathogen / EFSA J. 15
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