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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제10호
- 발행연도
- 2017.1
- 수록면
- 1,727 - 1,735 (9page)
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초록· 키워드
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Hepatitis E virus (HEV) infections cause epidemic or sporadic acute hepatitis, which are mostly self-limiting. However, viral infection in immunocompromised patients and pregnant women may result in serious consequences, such as chronic hepatitis and liver damage, mortality of the latter of which reaches up to 20-30%. Type I interferon (IFN)-induced antiviral immunity is known to be the first-line defense against virus infection. Upon HEV infection in the cell, the virus genome is recognized by pathogen recognition receptors, leading to rapid activation of intracellular signaling cascades. Expression of type I IFN triggers induction of a barrage of IFN-stimulated genes, helping the cells cope with viral infection.
Interestingly, some of the HEV-encoded genes seem to be involved in disrupting signaling cascades for antiviral immune responses, and thus crippling cytokine/chemokine production.
Antagonistic mechanisms of type I IFN responses by HEV have only recently begun to emerge, and in this review, we summarize known HEV evasion strategies and compare them with those of other hepatitis viruses.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Akira S / 2006 / Pathogen recognition and innate immunity / Cell 124 : 783 ~ 801
Graff J / 2006 / A bicistronic subgenomic mRNA encodes both the ORF2 and ORF3 proteins of hepatitis E virus / J. Virol 80 : 5919 ~ 5926
Graff J / 2008 / Mutations within potential glycosylation sites in the capsid protein of hepatitis E virus prevent the formation of infectious virus particles / J. Virol 82
Hardy MP / 2004 / Transcriptional regulation of the human TRIF (TIR domain-containing adaptor protein inducing interferon beta) gene / Biochem. J 380 : 83 ~ 93
Jameel S. / 1999 / Molecular biology and pathogenesis of hepatitis E virus / Expert Rev. Mol. Med : 1 ~ 16
Graff J / 2006 / A bicistronic subgenomic mRNA encodes both the ORF2 and ORF3 proteins of hepatitis E virus / J. Virol 80 : 5919 ~ 5926
Graff J / 2008 / Mutations within potential glycosylation sites in the capsid protein of hepatitis E virus prevent the formation of infectious virus particles / J. Virol 82
Hardy MP / 2004 / Transcriptional regulation of the human TRIF (TIR domain-containing adaptor protein inducing interferon beta) gene / Biochem. J 380 : 83 ~ 93
Jameel S. / 1999 / Molecular biology and pathogenesis of hepatitis E virus / Expert Rev. Mol. Med : 1 ~ 16
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