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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제20권 제12호
- 발행연도
- 2010.1
- 수록면
- 1,647 - 1,652 (6page)
이용수
초록· 키워드
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Autophagy refers to the bulk degradation of cellular proteins and organelles through an autophagosome and plays a pivotal role in the development, cellular differentiation,aging, and elimination of aberrant structures. A failure of autophagy has been implicated in a growing list of mammalian disease states, including cancer and cardiomyopathy. Two ubiquitin-like systems are highly involved in autophagy, especially in the formation of autophagosomes. Here, we purified and characterized Atg7 (an E1-like enzyme), and Atg3 and Atg10 (E2-like enzymes) in order to gain an insight into the role played by ubiquitin-like systems in the formation of autophagosomes.
Interestingly, we observed that Atg7 forms a homodimer to construct an active conformation, unlike other E1-like enzymes. Although Atg3 was detected as a monomer under physiological conditions, Atg10 existed in an oligomeric form, indicating that the mechanism by which Atg10 functions may differ from that of Atg3.
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참고문헌 (21)
참고문헌 신청
Abeliovich, H / 2000 / Dissection of autophagosome biogenesis into distinct nucleation and expansion steps / J. Cell Biol 151 : 1025 ~ 1034
Abeliovich, H / 2001 / Autophagy in yeast: Mechanistic insights and physiological function / Microbiol. Mol. Biol. Rev 65 : 463 ~ 479
Davenport, E. L / 2009 / Starving to succeed / Autophagy 5 : 1052 ~ 1054
Eisenberg-Lerner, A / 2009 / Life and death partners: Apoptosis, autophagy and the cross-talk between them / Cell Death Differ 16 : 966 ~ 975
Geng, J / 2008 / The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. ‘Protein modifications: Beyond the usual suspects’ review series / EMBO Rep 9 : 85
Abeliovich, H / 2001 / Autophagy in yeast: Mechanistic insights and physiological function / Microbiol. Mol. Biol. Rev 65 : 463 ~ 479
Davenport, E. L / 2009 / Starving to succeed / Autophagy 5 : 1052 ~ 1054
Eisenberg-Lerner, A / 2009 / Life and death partners: Apoptosis, autophagy and the cross-talk between them / Cell Death Differ 16 : 966 ~ 975
Geng, J / 2008 / The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. ‘Protein modifications: Beyond the usual suspects’ review series / EMBO Rep 9 : 85
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