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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Bacterial vaginosis (BV) and complicated vulvovaginal candidiasis (VVC) are frequently occurring vaginal infections inpostmenopausal women, caused by an imbalance in vaginal microflora. Postmenopausal women suffer from decreased ovarianhormones estrogen and progesterone. A normal, healthy vaginal microflora mainly comprises Lactobacillus species (spp.), whichact beneficially as a bacterial barrier in the vagina, interfering with uropathogens. During premenopausal period, estrogenpromotes vaginal colonization by lactobacilli that metabolizing glycogen and producing lactic acid, and maintains intravaginalhealth by lowering the intravaginal pH level. A lower vaginal pH inhibits uropathogen growth, preventing vaginal infections.
Decreased estrogen secretion in postmenopausal women depletes lactobacilli and increases intravaginal pH, resulting in increasedvaginal colonization by harmful microorganisms (e.g., Enterobacter, Escherichia coli, Candida, and Gardnerella). Probiotics positivelyeffects on vaginal microflora composition by promoting the proliferation of beneficial microorganisms, alters the intravaginalmicrobiota composition, prevents vaginal infections in postmenopausal. Probiotics also reduce the symptoms of vaginal infections(e.g., vaginal discharge, odor, etc.), and are thus helpful for the treatment and prevention of BV and VVC. In this review article,we provide information on the intravaginal mechanism of postmenopausal vaginal infections, and describes the effectiveness ofprobiotics in the treatment and prevention of BV and VVC. (J Menopausal Med 2017;23:139-145)
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참고문헌 (27)
참고문헌 신청
American Congress of Obstetricians and Gynecologists / 1996 / ACOG technical bulletin. Vaginitis. Number 226--July 1996(replaces No. 221, March 1996) / Int J Gynaecol Obstet
Anderson MR / 2004 / Evaluation of vaginal complaints / JAMA 291 : 1368 ~ 1379
Bodean O / 2013 / Probiotics--a helpful additional therapy for bacterial vaginosis / J Med Life 6 : 434 ~ 436
Bump RC / 1984 / The prevalence, six-month persistence, and predictive values of laboratory indicators of bacterial vaginosis (nonspecific vaginitis) in asymptomatic women /
Ceddia T / 1989 / Prevalence of non-specific vaginitis and correlation with isolation of Gardnerella vaginalis in Italian outpatients / Eur J Epidemiol 5 : 529 ~ 531
Anderson MR / 2004 / Evaluation of vaginal complaints / JAMA 291 : 1368 ~ 1379
Bodean O / 2013 / Probiotics--a helpful additional therapy for bacterial vaginosis / J Med Life 6 : 434 ~ 436
Bump RC / 1984 / The prevalence, six-month persistence, and predictive values of laboratory indicators of bacterial vaginosis (nonspecific vaginitis) in asymptomatic women /
Ceddia T / 1989 / Prevalence of non-specific vaginitis and correlation with isolation of Gardnerella vaginalis in Italian outpatients / Eur J Epidemiol 5 : 529 ~ 531
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