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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 100 - 105 (6page)
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While liver histopathology is heterogeneous in diabetes, the underlying mechanisms remain unclear. We investigated whether glycemic variation resulting from differential diets can induce heterogeneity in diabetic liver and the underlying molecular mechanisms. We generated end-stage non-obese diabetic model rats by subtotal-pancreatectomy in male Sprague- Dawley rats and ad libitum diet for 7 weeks (n = 33). The rats were then divided into three groups, and fed a standard- or a low-protein diet (18 or 6 kcal%, respectively), for another 7 weeks: to maintain hyperglycemia, 11 rats were fed ad libitum (18AL group); to achieve euglycemia, 11 were calorierestricted (18R group), and 11 were both calorie- and proteinrestricted with the low-protein diet (6R group). Overnightfasted liver samples were collected after the differential diets together with sham-control (18S group), and histology and molecular changes were compared. Hyperglycemic-18AL showed glycogenic hepatopathy (GH) without steatosis, with the highest GSK-3β inactivation because of Akt activation during hyperglycemia; mitochondrial function was not impaired, compared to the 18S group. Euglycemic-18R showed neither GH nor steatosis, with intermediate GSK-3β activation and mitochondrial dysfunction. However, euglycemic-6R showed both GH and steatosis despite the highest GSK-3β activity and no molecular evidence of increased lipogenesis or decreased ApoB expression, where mitochondrial dysfunction was highest among the groups. In conclusion, heterogeneous liver histopathology developed in end-stage non-obese diabetic rats as the glycemic levels varied with differential diets, in which protein content in the diets as well as glycemic levels differentially influenced GSK-3β activity and mitochondrial function in insulin-deficient state.
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참고문헌 (26)
참고문헌 신청
Adams LA / 2010 / Nonalcoholic fatty liver disease increases risk of death among patients with diabetes : a community-based cohort study / Am J Gastroenterol 105:1567~1573
Roden M / 2006 / Mechanisms of Disease : hepatic steatosis in type 2 diabetes-pathogenesis and clinical relevance / Nat Clin Pract Endocrinol Metab 2:335~348
Torbenson M / 2006 / Glycogenic hepatopathy: an underrecognized hepatic complication of diabetes mellitus / Am J Surg Pathol 30:508~513
Harrison SA / 2006 / Diabetic hepatosclerosis: diabetic microangiopathy of the liver / Arch Pathol Lab Med 130:27~32
Fioretto P / 1996 / Patterns of renal injury in NIDDM patients with microalbuminuria / Diabetologia 39:1569~1576
Roden M / 2006 / Mechanisms of Disease : hepatic steatosis in type 2 diabetes-pathogenesis and clinical relevance / Nat Clin Pract Endocrinol Metab 2:335~348
Torbenson M / 2006 / Glycogenic hepatopathy: an underrecognized hepatic complication of diabetes mellitus / Am J Surg Pathol 30:508~513
Harrison SA / 2006 / Diabetic hepatosclerosis: diabetic microangiopathy of the liver / Arch Pathol Lab Med 130:27~32
Fioretto P / 1996 / Patterns of renal injury in NIDDM patients with microalbuminuria / Diabetologia 39:1569~1576
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