지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 30 - 36 (7page)
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초록· 키워드
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Objectives: The objective of the study was to prepare Bauhinia variegata loaded nanoemulsion(formulation and determine the efficacy of herbal drug formulation against diabetic peripheral neuropathic pain through acupuncture technique. Methods: Nine different ba tches of nanoemulsion (NE1 NE9) of BVN was prepared by varying the S mix ratio and the concentration of oil. BVN was characterized to determine particle size, shape, zeta potential, polydispersity index, optical transmittance, drug release profile and stora ge stability. The optimized formulation was subjected to plantar test, behavioral tests of neuropathic pain and Von Frey filament stimulation test. Diabetes was induced by intraperitoneal injection of freshly prepared solution of Streptozotocin (60 mg/kg) to the experimental rats. Animals were made diabetic divided into four groups, Group I was untreated normal control group, Group II was diabetic control group, Group III was Bauhinia variegata extract ( treated group (100 mg/kg/day, p.o) and Group IV was BVN treated groups (100 mg/kg/day, p.o) acute and chronically. Results: The prepared B. variegata loaded nanoemulsion was nanosized (124 nm), spherical, uniform and stable over the period of 180 days with no change in physiochemical properties. The bl ood glucose and body weight of animals was normalizing after four weeks of treatment that was significant with BVN in comparison to diabetic control group. The chronic administration of BVN significantly (P<0.001) decreased hind paw withdrawal latency an d attenuated mechanical allodynia as compared with diabetic rats. Conclusion: Thus, BVN may be an effective drug formulation against diabetic peripheral neuropathic pain.
목차
등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Fangueiro JF / 2015 / European Journal of Pharmaceutics and Biopharmaceutics Current nanotechnology approaches for the treatment and management of diabetic retinopathy / Eur J Pharm Biopharm 95:307~322
Kesharwani P / 2017 / Nanotechnology based approaches for anti-diabetic drugs delivery / Diabetes Res Clin Pract 136:52~77
Landon MB / 2009 / Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network, A multicenter, randomized trial of treatment for mild gestational diabetes / N Engl J Med 361:1339~1348
Ziegler D / 2008 / Painful diabetic neuropathy : treatment and future aspects / Diabetes Metab Res Rev 24(1):S52~S57
Teeranachaideekul V / 2008 / Influence of oil content on physicochemical properties and skin distribution of nile red-loaded NLC / J Control Release 128(2):134~141
Kesharwani P / 2017 / Nanotechnology based approaches for anti-diabetic drugs delivery / Diabetes Res Clin Pract 136:52~77
Landon MB / 2009 / Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network, A multicenter, randomized trial of treatment for mild gestational diabetes / N Engl J Med 361:1339~1348
Ziegler D / 2008 / Painful diabetic neuropathy : treatment and future aspects / Diabetes Metab Res Rev 24(1):S52~S57
Teeranachaideekul V / 2008 / Influence of oil content on physicochemical properties and skin distribution of nile red-loaded NLC / J Control Release 128(2):134~141
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