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논문 기본 정보

자료유형
학술저널
저자정보
Ahn, Byoung-Ok (Research Laboratories, Dong-A Pharm, Co, Ltd.) Ryu, Byong-Kweon (Research Laboratories, Dong-A Pharm, Co, Ltd.) Ko, Jun-Il (Research Laboratories, Dong-A Pharm, Co, Ltd.) Oh, Tae-Young (Research Laboratories, Dong-A Pharm, Co, Ltd.) Kim, Soon-Hoe (Research Laboratories, Dong-A Pharm, Co, Ltd.) Kim, Won-Bae (Research Laboratories, Dong-A Pharm, Co, Ltd.) Yang, Jun-Nick (Research Laboratories, Dong-A Pharm, Co, Ltd.) Lee, Eun-Bang (Natural Prosucts Instiute, Seoul National Unicersity) Hahm, Ki-Baik (Department of Gastroenterology, College of Medicine, Ajou University)
저널정보
한국응용약물학회 The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology 제5권 제2호
발행연도
1997.1
수록면
165 - 173 (9page)

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This study was conducted to investigate the effect of DA-9601, an extract of Artemisiae Herba, which is known to possess mucoprotective action either by free radical scavenging effect or increase of mucus secretion, against animal models of inflammatory bowel disease (IBD) induced by trinirobenzene sulfonic acid (TNBS) or other noxious agents. Experimental colitis was induced by intracolonic administration of TNBS in 50% ethanol, or 1 ml of 7% acetic acid solution (AA), by subcutaneous injection of indomethacin (INDO) in rats, or by supplementing drinking water with 5% dextran sodium sulfate (DSS) in albino mice. DA-9601 was treated orally for 4 to 7 days. Animals were euthanized 1 day after the last treatment for morphological and biochemical analysises. All the noxious agents including TNBS, AA, INDO and DSS elicited severe colitis. The animals treated with DA-9601 showed a consistent, dose-related reduction in the severity of colitis, grossly and histologically. The reduction was significant (p<0.05) after administration of DA-9601 at dose range of 10 mg/kg or above. In TNBS-induced colitis, the rats receiving DA-9601 showed significantly decreased mucosal myeloperoxidase (MPO) and thiobarbituric acid-reactive substances (TBA-RS), when compared to control and mesalazine groups. Mucosal proinflammatory cytokine levels were also decreased after DA-9601 treatment. In conclusion, DA-9601 ameliorated macroscopic and histologic scores in experimental colitis either through decreasing oxidative stress or by attenuating cytokines involved in inflammation. DA-9601 could be a promising drug for the therapy of IBD.

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