지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제21권 제5호
- 발행연도
- 1998.1
- 수록면
- 531 - 536 (6page)
이용수
초록· 키워드
오류제보하기
We had previously reported that the protective effect of taurine against indomethacin-induced gastric mucosal injury was due to its antioxidant effects, which inhibited lipid peroxidation and neutrophil activation. In this study, we examined the effect of taurine on reducing the inflammatory parameters of trintrobenzene sulfonic acid (TNBS)-induced inflammatory bowel disease (IBD) in rats. In order to induce IBD, ethanolic TNBS was given to rats intracolonically. Then they received 500 mg/kg.day of taurine orally and were sacrificed one week after IBD induction. While ulceration and inflammation of distal colon with formation of granuloma in the vehicle-treated IBD rats two days after administration of TNBS were observed, treatment with taurine ameliorated colonic damage and decreased the incidence of diarrhea and adhesion. also, colon weight as an index of tissue edema, which was mardedly increased in the IBD rats, became significantly lower after administration of TNBS were observed, treatment with taurine ameliorated colonic damage and decreased the incidence of diarrhea and adhesion. Also colon weitht as an index of tissue edema, which was markedly increased in the IBD rats, became significantly lower after taruine treatment. Myeloperoxidase (MPO) activity in the vehicle-treated IBD rats was substantially increased, compared with that of normal control. the taurine-treated animals significantly reduced MPO activity (35% lower) when compared with that of the vehicle-treated animals. Taurine treatment decreased both basal and formyl-methionyl leucyl phenylalanine-stimulated reactive oxygen generation from colonic tissue in the IBD rats. These results suggest that the administration of taurine reduce the inflammatory parameters in this IBD rat model by increasing defending capacity against oxidative damage.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Perspectives on Current and Novel Treatments for Inflammatory Bowel Disease
Gut and Liver
2019 .01
-
소아기에 발병하는 염증성장질환(IBD)은 성인 IBD와 다른 질환인가? - 조기발병 소아 IBD의 역학적, 임상적, 유전학적 특성 및 치료 시 고려 사항-
Pediatric Gastroenterology, Hepatology & Nutrition
2011 .01
-
Effect of DA-6034, a Derivative of Flavonoid, on Experimental Animal Models of Inflammatory Bowel Disease
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1999 .01
-
Pathogenesis of Inflammatory Bowel Disease and Recent Advances in Biologic Therapies
Immune Network
2017 .02
-
Effect of Dioscorea Rhizoma powder on TNBS-induced IBD Model of Mice
한국실험동물학회 학술발표대회 논문집
2010 .08
-
Fusobacterium Isolates Recovered From Colonic Biopsies of Inflammatory Bowel Disease Patients in Korea
Annals of Laboratory Medicine
2016 .01
-
Current issues of pediatric inflammatory bowel disease in Korea
Clinical and Experimental Pediatrics
2014 .01
-
Inflammatory Bowel Disease in Korea: Epidemiological, Genomic, Clinical, and Therapeutic Characteristics
Gut and Liver
2010 .01
-
Disability due to Inflammatory Bowel Disease Is Correlated with Drug Compliance, Disease Activity, and Quality of Life
Gut and Liver
2017 .01
-
Changes in Direct Healthcare Costs before and after the Diagnosis of Inflammatory Bowel Disease: A Nationwide Population-Based Study
Gut and Liver
2020 .01
-
Gastritis Associated with Initially Pediatric Crohn’s Disease andUlcerative Colitis
Pediatric Gastroenterology, Hepatology & Nutrition
2018 .01
-
Optimizing the Use of Current Treatments and Emerging Therapeutic Approaches to Achieve Therapeutic Success in Patients with Inflammatory Bowel Disease
Gut and Liver
2020 .01
-
Protective effects of Pogostemon cablin Bentham water extract on inflammatory cytokine expression in TNBS-induced colitis in rats
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2014 .01
-
Impact of Education on School Nurses’ Knowledge of Inflammatory Bowel Disease
Gut and Liver
2019 .01
-
Beneficial Effect of DA-9601, an Extract of Artemisiae Herba, on Animals Models of Inflammatory Bowel Disease
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
1997 .01
-
The Early Onset of Disease May Be a Risk Factor for Decreased Bone Mineral Density in Patients with Inflammatory Bowel Disease
Clinical Endoscopy
2013 .01
-
The Effect of the Menstrual Cycle on Inflammatory Bowel Disease: A Prospective Study
Gut and Liver
2013 .01
-
Higher Morbidity of Monogenic Inflammatory Bowel Disease Compared to the Adolescent Onset Inflammatory Bowel Disease
Pediatric Gastroenterology, Hepatology & Nutrition
2018 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0