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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 104 - 109 (6page)
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Probenecid is a representative drug used in the treatment of gout. A recent study showed that probenecid effectively inhibits oxidative stress in neural cells. In the present study, we investigated whether probenecid can affect osteoclast formation through the inhibition of reactive oxygen species (ROS) formation in RAW264.7 cells. Lipopolysaccharide (LPS)-induced ROS levels were dose-dependently reduced by probenecid. Fluorescence microscopy analysis clearly showed that probenecid inhibits the generation of ROS. Western blot analysis indicated that probenecid affects two downstream signaling molecules of ROS, cyclooxygenase 2 (COX-2) and c-Jun N-terminal kinase (JNK). These results indicate that probenecid inhibits ROS generation and exerts antiosteoclastogenic activity by inhibiting the COX-2 and JNK pathways. These results suggest that probenecid could potentially be used as a therapeutic agent to prevent bone resorption.
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참고문헌 (45)
참고문헌 신청
Bae, Y. S. / 1997 / Epidermal growth factor (EGF)-induced generation of hydrogen peroxide. Role in EGF receptor-mediated tyrosine phosphorylation / J. Biol. Chem 272:217~221
Beachwood, E. C. / 1964 / Stop-flow analysis of tubular transport of uric acid in rabbits / Am. J. Physiol 207:1265~1272
Bishop, C. / 1955 / Immediate uricosuric effect of probenecid in normal humans / Proc. Soc. Exp. Biol. Med 88:346~348
Boger, W. P. / 1955 / Probenecid (benemid); Its uses and side-effects in 2,502 patients / AMA Arch. Intern. Med 95:83~92
Boyle, W. J. / 2003 / Osteoclast differentiation and activation / Nature 423:337~342
Beachwood, E. C. / 1964 / Stop-flow analysis of tubular transport of uric acid in rabbits / Am. J. Physiol 207:1265~1272
Bishop, C. / 1955 / Immediate uricosuric effect of probenecid in normal humans / Proc. Soc. Exp. Biol. Med 88:346~348
Boger, W. P. / 1955 / Probenecid (benemid); Its uses and side-effects in 2,502 patients / AMA Arch. Intern. Med 95:83~92
Boyle, W. J. / 2003 / Osteoclast differentiation and activation / Nature 423:337~342
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