The rs61764370 Functional Variant in the KRAS Oncogene is Associated with Chronic Myeloid Leukemia Risk in Women

Gutierrez-Malacatt, Humberto; Ayala-Sanchez, Manuel; Aquino-Ortega, Xochitl; Dominguez-Rodriguez, Jacqueline; Martinez-Tovar, Adolfo; Olarte-Carrillo, Irma; Martinez-Hernandez, Angelica; Cecilia, Contreras-Cubas C; Orozco, Lorena; Cordova, Emilio J

추천

검색

자료유형: 학술저널

저자정보: Gutierrez-Malacatt, Humberto (Posgrado en Ciencias Biologicas, Universidad Nacional Autonoma de Mexico) Ayala-Sanchez, Manuel (Service of Hematology, Hospital de Especialidades) Aquino-Ortega, Xochitl (Service of Hematology, Hospital de Especialidades) Dominguez-Rodriguez, Jacqueline (Service of Hematology, Hospital de Especialidades) Martinez-Tovar, Adolfo (Department of Hematology, Hospital General de Mexico) Olarte-Carrillo, Irma (Department of Hematology, Hospital General de Mexico) Martinez-Hernandez, Angelica (Immunogenomics and Metabolic Diseases Laboratory, Instituto Nacional de Medicina Genomica, INMEGEN) Cecilia, Contreras-Cubas C (Immunogenomics and Metabolic Diseases Laboratory, Instituto Nacional de Medicina Genomica, INMEGEN) Orozco, Lorena (Immunogenomics and Metabolic Diseases Laboratory, Instituto Nacional de Medicina Genomica, INMEGEN) Cordova, Emilio J (Immunogenomics and Metabolic Diseases Laboratory, Instituto Nacional de Medicina Genomica, INMEGEN)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제17권 제4호

발행연도: 2016.1

수록면: 2,265 - 2,270 (6page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Background: Chronic myeloid leukemia (CML) is one of the most frequent hematopoietic malignancies in the elderly population; however, knowledge is limited regarding the genetic factors associated with increased risk for CML. Polymorphisms affecting microRNA (miRNA) biogenesis or mRNA:miRNA interactions are important risk factors in the development of different types of cancer. Thus, we carried out a case-control study to test the association with CML susceptibility of gene variants located in the miRNA machinery genes AGO1 (rs636832) and GEMIN4 (rs2740348), as well as in the miRNA binding sites of the genes BRCA1 (rs799917) and KRAS (rs61764370). Materials and Methods: We determined the genotype of 781 Mexican-Mestizo individuals (469 healthy subjects and 312 CML cases) for the four polymorphisms using TaqMan probes to test the association with CML susceptibility. Results: We found a borderline association of the minor homozygote genotype of the KRAS_rs61764370 polymorphism with an increased risk for CML susceptibility (P = 0.06). After gender stratification, this association was significant only for women (odds ratio [OR] = 13.41, P = 0.04). The distribution of the allelic and genotypic frequencies of the four studied SNPs was neither associated with advanced phases of CML nor treatment response. Conclusions: To the best of our knowledge, this study is the first to show a significant association of the KRAS_rs61764370 SNP with CML. To further determine such an association of with CML susceptibility, our results must be replicated in different ethnic groups.

#CML #polymorphisms #microRNAs #KRAS

참고문헌 (0)

참고문헌 신청

참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!