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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 177 - 179 (3page)
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Dear Editor, The mechanisms involved in chronic myeloid leukemia (CML) progression from the chronic phase (CP) to an accelerated phase (AP) or blast crisis (BC) remain largely undetermined, but generally involve additional molecular changes besides the Philadelphia chromosome [1]. Evidence suggests that secondary BCR (breakpoint cluster region)-ABL1 (Abelson murine leukemia viral oncogene homolog 1)-dependent/independent genetic events play a critical role in blast transformation [2]. Besides BCR-ABL1 point mutations, deletions and/or rearrangements of other cancer-related genes have been associated with CML-BC [2]. Recent studies have demonstrated that aberrant activation-induced cytidine deaminase (AID) expression promotes genetic instability, eventually leading to progression and drug resistance in CML [3].
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참고문헌 (10)
참고문헌 신청
Dose M / 2014 / β-Catenin induces T-cell transformation by promoting genomic instability / Proc Natl Acad Sci U S A 111 : 391 ~ 396
Feldhahn N / 2007 / Activation-induced cytidine deaminase acts as a mutator in BCR-ABL1-transformed acute lymphoblastic leukemia cells / J Exp Med 204 : 1157 ~ 1166
Jamieson CH / 2004 / Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML / N Engl J Med 351 : 657 ~ 667
Kato L / 2012 / Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes / Proc Natl Acad Sci U S A 109 :
Klemm L / 2009 / The B cell mutator AID promotes B lymphoid blast crisis and drug resistance in chronic myeloid leukemia / Cancer Cell 16 : 232 ~ 245
Feldhahn N / 2007 / Activation-induced cytidine deaminase acts as a mutator in BCR-ABL1-transformed acute lymphoblastic leukemia cells / J Exp Med 204 : 1157 ~ 1166
Jamieson CH / 2004 / Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML / N Engl J Med 351 : 657 ~ 667
Kato L / 2012 / Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes / Proc Natl Acad Sci U S A 109 :
Klemm L / 2009 / The B cell mutator AID promotes B lymphoid blast crisis and drug resistance in chronic myeloid leukemia / Cancer Cell 16 : 232 ~ 245
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