Detection of BCR/ABL Fusion Gene by Hematological and Cytogenetical Analysis in Chronic Myeloid Leukemia Patients in Quetta, Pakistan

Tahira, Bibi; Asif, Muhammad; Khan, Samiullah; Hussain, Abrar; Shahwani, Muhammad Naeem; Malik, Arif; Inayatullah, Syed; Iqbal, Zafar; Rasool, Mahmood

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저자정보: Tahira, Bibi (Department of Biotechnology, Balochistan University of Information Technology, Engineering and Management Sciences) Asif, Muhammad (Department of Biotechnology, Balochistan University of Information Technology, Engineering and Management Sciences) Khan, Samiullah (Department of Biotechnology, Balochistan University of Information Technology, Engineering and Management Sciences) Hussain, Abrar (Department of Biotechnology, Balochistan University of Information Technology, Engineering and Management Sciences) Shahwani, Muhammad Naeem (Department of Biotechnology, Balochistan University of Information Technology, Engineering and Management Sciences) Malik, Arif (Institute of Molecular Biology and Biotechnology, The University of Lahore) Inayatullah, Syed (Department of Biotechnology, Balochistan University of Information Technology, Engineering and Management Sciences) Iqbal, Zafar (College of Applied Medical Sciences, King Saud Bin Abdulaziz University for Health Sciences, National Guards Health Affairs) Rasool, Mahmood (Center of Excellence in Genomic Medicine Research [CEGMR], King Abdulaziz University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제9호

발행연도: 2015.1

수록면: 3,793 - 3,797 (5page)

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Background: Chronic myeloid leukemia (CML) is a myeloproliferative disorder of pluripotent stem cells, caused by reciprocal translocation between the long arms of chromosomes 9 and 22, t(9;22)(q34;q11), known as the Philadelphia chromosome. Materials and Methods: A total of 51 CML patients were recruited in this study. Complete blood counts of all CML patients were performed to find out their total leukocytes, hemoglobin and platelets. FISH was performed for the detection of BCR-ABL fusion and cryptogenic tests using bone marrow samples were performed for the conformation of Ph (9;22)(q34;q11) and variant translocation mechanisms. Results: In cytogenetic analysis we observed that out of 51 CML patients 40 (88.9%) were Ph positive and 4 (8.88%) had Ph negative chromosomes. Mean values of WBC 134.5 $10^3/{\mu}l$, hemoglobin 10.44 mg/dl, and platelets 288.6 $10^3/{\mu}l$ were observed in this study. Conclusions: In this study, Ph positive translocation between chromosome (9:22)(q34;q11) were observed in 40 (88.9%) CML patients.

#Chronic myeloid leukemia #ph chromosome #variant translocation #matinib mesylate

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Tahira, Bibi

소속기관 Department of Biotechnology, Balochistan University of Information Technology, Engineering and Manag