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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.9
- 수록면
- 136 - 148 (13page)
이용수
DBpia Top 0.5%동일한 주제분류 기준으로최근 2년간 이용수 순으로 정렬했을 때
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초록· 키워드
오류제보하기
A bispecific antibody (BsAb) is an artificial protein containing two kinds of specific antigen binding sites. BsAb can connect target cells to functional cells or molecules, and thus stimulate a directed immune response. Last several decades a wide variety of bsAb formats and production technologies have been developed. BsAbs are constructed either chemically or biologically, exploiting techniques like cell fusion and recombinant DNA technologies. There are over 100 different formats of bsAb so far developed, but they could be classified into the two main categories such as Fc-based (with a Fc region) bsAbs and fragment-based (without a Fc region) bsAbs. BsAb has a broad application prospect in tumor immunotherapy and drug delivery. Here, we present a brief introduction to the structure of antibody, pharmacological mechanisms of antibodies and the trend in the production technologies of therapeutic antibodies. In addition, we address a review on the current status of various bsAb format development and their production technologies together with global situation in the clinical studies of bsAb.
목차
1. 서론
2. 바이오 의약품 시장 현황
3. 항체치료제 개발 현황
4. 항체의 약리작용
5. 항체와 단편항체의 구조
6. 치료용 항체 제조기술 동향
7. 이중항체
8. 이중항체의 제조방법과 형식(format)
9. 이중항체의 글로벌 연구 현황
10. 이중항체의 국내 연구 현황
11. 논의
REFERENCES
참고문헌 (47)
참고문헌 신청
2019 / 2019 Pharmaceutical Industry DATABOOK Statistic Information / KPBMA (Korea Pharmaceutical and Bio-Pharma Manufacturers Association)
Abclon / homepage
ABLBio / homepage
Almagro JC / 2008 / Humanization of antibodies / Front Biosci 13:1619~1633
Brinkmann U / 2017 / The making of bispecific antibodies / MAbs 9:182~212
Abclon / homepage
ABLBio / homepage
Almagro JC / 2008 / Humanization of antibodies / Front Biosci 13:1619~1633
Brinkmann U / 2017 / The making of bispecific antibodies / MAbs 9:182~212
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UCI(KEPA) : I410-ECN-0101-2020-510-001306071