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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제30권 제12호
- 발행연도
- 2020.1
- 수록면
- 1,801 - 1,809 (9page)
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초록· 키워드
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Chikungunya virus (CHIKV) was first identified in 1952 as a causative agent of outbreaks. CHIKV is transmitted by two mosquito species, Aedes aegypti and A. albopictus. Symptoms after CHIKV infection in human are typically fever and joint pain, but can also include headache, muscle pain, joint swelling, polyarthralgia, and rash. CHIKV is an enveloped single-stranded, positive-sense RNA virus with a diameter of approximately 70 nm. The pathogenesis of CHIKV infection and the mechanism by which the virus evades the innate immune system remain poorly understood. Moreover, little is known about the roles of CHIKV-encoded genes in the viral evasion of host immune responses, especially type I interferon (IFN) responses. Therefore, in the present study, we screened CHIKV-encoded genes for their regulatory effect on the activation of nuclear factor kappa B (NF-κB), a critical transcription factor for the optimal activation of IFN-β. Among others, nonstructural protein 2 (nsP2) strongly inhibited melanoma differentiation-associated protein 5 (MDA5)-mediated induction of the NF-κB pathway in a dose-dependent manner. Elucidation of the detailed mechanisms of nsP2-mediated inhibition of the MDA5/RIG-I signaling pathway is anticipated to contribute to the development of virus-specific therapeutics against CHIKV infection.
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참고문헌 (36)
참고문헌 신청
배소정 / 2019 / Chikungunya Virus-Encoded nsP2, E2 and E1 Strongly Antagonize the Interferon-β Signaling Pathway / Journal of Microbiology and Biotechnology 29(11):1852~1859
Burt FJ / 2017 / Chikungunya virus : an update on the biology and pathogenesis of this emerging pathogen / Lancet Infect. Dis 17:e107~e117
Bustos Carrillo F / 2019 / Epidemiological evidence for lineage-specific differences in the risk of inapparent chikungunya virus infection / J. Virol 93:e1622
Zhang YN / 2019 / Infectious chikungunya virus(CHIKV)with a complete capsid deletion : a new approach for a CHIKV vaccine / J. Virol 93:e00504
Kato H / 2006 / Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses / Nature 441:101~105
Burt FJ / 2017 / Chikungunya virus : an update on the biology and pathogenesis of this emerging pathogen / Lancet Infect. Dis 17:e107~e117
Bustos Carrillo F / 2019 / Epidemiological evidence for lineage-specific differences in the risk of inapparent chikungunya virus infection / J. Virol 93:e1622
Zhang YN / 2019 / Infectious chikungunya virus(CHIKV)with a complete capsid deletion : a new approach for a CHIKV vaccine / J. Virol 93:e00504
Kato H / 2006 / Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses / Nature 441:101~105
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