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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 12 - 20 (9page)
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Purpose: Alpha-fetoprotein (AFP) is a prognostic marker for hepatocellular carcinoma (HCC). We investigated the prognosticvalue of AFP levels in patients who achieved complete response (CR) to transarterial chemoembolization (TACE) for HCC. Materials and Methods: Between 2005 and 2018, 890 patients with HCC who achieved a CR to TACE were recruited. An AFP responderwas defined as a patient who showed elevated levels of AFP (>10 ng/mL) during TACE, but showed normalization or a>50% reduction in AFP levels after achieving a CR. Results: Among the recruited patients, 569 (63.9%) with naive HCC and 321 (36.1%) with recurrent HCC after complete resectionwere treated. Before TACE, 305 (34.3%) patients had multiple tumors, 219 (24.6%) had a maximal tumor size >3 cm, and 22 (2.5%)had portal vein tumor thrombosis. The median AFP level after achieving a CR was 6.36 ng/mL. After a CR, 473 (53.1%) patientsexperienced recurrence, and 417 (46.9%) died [median progression-free survival (PFS) and overall survival (OS) of 16.3 and 62.8months, respectively]. High AFP levels at CR (>20 ng/mL) were independently associated with a shorter PFS [hazard ratio(HR)=1.403] and OS (HR=1.284), together with tumor multiplicity at TACE (HR=1.518 and 1.666, respectively). AFP non-respondersat CR (76.2%, n=359 of 471) showed a shorter PFS (median 10.5 months vs. 15.5 months, HR=1.375) and OS (median 41.4months vs. 61.8 months, HR=1.424) than AFP responders (all p=0.001). Conclusion: High AFP levels and AFP non-responders were independently associated with poor outcomes after TACE. AFP holdsclinical implications for detailed risk stratification upon achieving a CR after TACE.
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참고문헌 (39)
참고문헌 신청
European Association for the Study of the Liver / 2018 / EASL Clinical Practice Guidelines : Management of hepatocellular carcinoma / J Hepatol 69:182~236
Kim BK / 2012 / Applicability of BCLC stage for prognostic stratification in comparison with other staging systems : single centre experience from longterm clinical outcomes of 1717 treatment-naïve patients with hepatocellular carcinoma / Liver Int 32:1120~1127
Yu SJ / 2016 / A concise review of updated guidelines regarding the management of hepatocellular carcinoma around the world : 2010-2016 / Clin Mol Hepatol 22:7~17
한국 간 암 스터디그룹 / 2015 / 2014 KLCSG-NCC Korea Practice Guideline for the Management of Hepatocellular Carcinoma / Gut and Liver 9(3):267~317
김준영 / 2016 / Transarterial chemoembolization versus resection for the intermediate stage hepatocellular carcinoma / Clinical and Molecular Hepatology 22(2):250~258
Kim BK / 2012 / Applicability of BCLC stage for prognostic stratification in comparison with other staging systems : single centre experience from longterm clinical outcomes of 1717 treatment-naïve patients with hepatocellular carcinoma / Liver Int 32:1120~1127
Yu SJ / 2016 / A concise review of updated guidelines regarding the management of hepatocellular carcinoma around the world : 2010-2016 / Clin Mol Hepatol 22:7~17
한국 간 암 스터디그룹 / 2015 / 2014 KLCSG-NCC Korea Practice Guideline for the Management of Hepatocellular Carcinoma / Gut and Liver 9(3):267~317
김준영 / 2016 / Transarterial chemoembolization versus resection for the intermediate stage hepatocellular carcinoma / Clinical and Molecular Hepatology 22(2):250~258
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