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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 1,049 - 1,054 (6page)
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초록· 키워드
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Pretransplant alpha-fetoprotein (AFP) is a useful tumor marker predicting recurrence of hepatocellular carcinoma (HCC). Little is known, however, about the relationship between changes in AFP concentration and prognosis. This study investigated the clinical significance of change in peri-transplant AFP level as a predictor of HCC recurrence. Data from 125 HCC patients with elevated pretransplant AFP level who underwent liver transplantation (LT) between February 2000 and December 2010 were retrospectively reviewed. Patients with AFP normalization within 1 month after LT were classified into the rapid normalization group (n = 97), with all other patients classified into the non-rapid normalization group (n = 28). Tumor recurrence was observed in 17 of the 97 patients (17.5%) with rapid normalization; of these, 11 patients had high AFP levels and six had normal levels at recurrence. In contrast, tumor recurrence was observed in 24 of the 28 patients (85.7%) without rapid normalization, with all 24 having high AFP levels at recurrence. Multivariate analysis showed that non-rapid normalization (harzard ratio [HR], 4.41, P < 0.001), sex (HR, 3.26, P = 0.03), tumor size (HR, 1.15, P = 0.001), and microvascular invasion (HR, 2.65, P = 0.005) were independent risk factors for recurrence. In conclusion, rapid normalization of post-LT AFP level at 1 month is a useful clinical marker for HCC recurrence. Therefore, an adjuvant strategy and/or intensive screening are needed for patients who do not show rapid normalization.
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참고문헌 (13)
참고문헌 신청
Debruyne EN / 2008 / Diagnosing and monitoring hepatocellular carcinoma with alpha-fetoprotein : new aspects and applications / Clin Chim Acta 395:19~26
Trevisani F / 2001 / Serum alpha-fetoprotein for diagnosis of hepatocellular carcinoma in patients with chronic liver disease : influence of HBsAg and anti-HCV status / J Hepatol 34:570~575
Yao FY / 2001 / Liver transplantation for hepatocellular carcinoma : expansion of the tumor size limits does not adversely impact survival / Hepatology 33:1394~1403
Zou WL / 2008 / Risk factors for fatal recurrence of hepatocellular carcinoma and their role in selecting candidates for liver transplantation / Hepatobiliary Pancreat Dis Int 7:145~151
Wang ZX / 2010 / A single-center retrospective analysis of liver transplantation on 255 patients with hepatocellular carcinoma / Clin Transplant 24:752~757
Trevisani F / 2001 / Serum alpha-fetoprotein for diagnosis of hepatocellular carcinoma in patients with chronic liver disease : influence of HBsAg and anti-HCV status / J Hepatol 34:570~575
Yao FY / 2001 / Liver transplantation for hepatocellular carcinoma : expansion of the tumor size limits does not adversely impact survival / Hepatology 33:1394~1403
Zou WL / 2008 / Risk factors for fatal recurrence of hepatocellular carcinoma and their role in selecting candidates for liver transplantation / Hepatobiliary Pancreat Dis Int 7:145~151
Wang ZX / 2010 / A single-center retrospective analysis of liver transplantation on 255 patients with hepatocellular carcinoma / Clin Transplant 24:752~757
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