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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 83 - 88 (6page)
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Treatment guidelines for postnatal cytomegalovirus (pCMV) infection in preterm have not been established yet. Neutropenia, thrombocytopenia, hepatitis, colitis, and sepsis-like disease are among the clinical manifestations, which range from moderate to serious. We present a case of autopsy diagnosed as pCMV infection in a premature infant delivered at gestational age of 24 weeks and 5 days. On the 7th and 14th days of birth, urinary CMV polymerase chain reaction samples were negative, ruling out congenital CMV infection. However, autopsy examination revealed that the patient had disseminated pCMV infection. CMV inclusion bodies were found in the majority of tissues, including the lung, liver, pancreas, breast, kidney, and adrenal gland, but not the placenta. The thymus exhibited significant cortical atrophy and T-cell immunodeficiency, possibly induced by dexamethasone treatment for bronchopulmonary dysplasia or by pCMV infection itself. If dexamethasone treatment is extended or high doses are considered, it may be beneficial to test the CMV infection status to prevent aggravation of infection. This case demonstrates that, despite the low prevalence, pCMV infection should be considered a differential diagnosis in preterm if other conditions or etiology cannot justify clinical deterioration.
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참고문헌 (16)
참고문헌 신청
Bialas KM / 2015 / Perinatal cytomegalovirus infections : epidemiology, prevention, and treatment / NeoReviews 16:e231~e235
최새롬 / 2018 / Changes in Cytomegalovirus Seroprevalence in Korea for 21 Years: a Single Center Study / Pediatric Infection and Vaccine 25(3):123~131
Rawlinson WD / 2017 / Congenital cytomegalovirus infection in pregnancy and the neonate : consensus recommendations for prevention, diagnosis, and therapy / Lancet Infect Dis 17:e177~e188
Yasuda A / 2003 / Evaluation of cytomegalovirus infections transmitted via breast milk in preterm infants with a real-time polymerase chain reaction assay / Pediatrics 111(6 Pt 1):1333~1336
Stehel EK / 2005 / Cytomegalovirus infection in the fetus and neonate / NeoReviews 6:e38~e45
최새롬 / 2018 / Changes in Cytomegalovirus Seroprevalence in Korea for 21 Years: a Single Center Study / Pediatric Infection and Vaccine 25(3):123~131
Rawlinson WD / 2017 / Congenital cytomegalovirus infection in pregnancy and the neonate : consensus recommendations for prevention, diagnosis, and therapy / Lancet Infect Dis 17:e177~e188
Yasuda A / 2003 / Evaluation of cytomegalovirus infections transmitted via breast milk in preterm infants with a real-time polymerase chain reaction assay / Pediatrics 111(6 Pt 1):1333~1336
Stehel EK / 2005 / Cytomegalovirus infection in the fetus and neonate / NeoReviews 6:e38~e45
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