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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 1 - 11 (11page)
- DOI
- 10.3346/jkms.2021.36.e239
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초록· 키워드
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Background: Risk of fragility fractures increases in patients with diabetes mellitus, independent of bone mineral density. In the present study, the effects of advanced glycation end products (AGEs) on differentiation and function of osteoblasts and osteoclasts were investigated.
Methods: AGEs and 25 mM glucose were administered to marrow-derived macrophages and MCT3T3-E1 cells. The effects of AGEs on osteoclast differentiation was investigated using tartrate-resistant acid phosphatase (TRAP) assay. The effects of AGEs on osteoblast differentiation was investigated using alkaline phosphatase (ALP) activity and bone nodule formation assays. Expression of osteoclast-specific and osteoblast-specific genes and effects on cell signaling pathways associated with cell differentiation were analyzed using reverse transcription polymerase chain reaction and western blotting.
Results: AGEs significantly decreased TRAP-positive multinucleated cell formation in receptor activator of nuclear factor-κB ligand-induced marrow-derived macrophages in a dose-dependent manner. AGEs suppressed the expression of osteoclast-specific genes, JNK, p38, AKT, intercellular adhesion molecule 1, and lymphocyte function-associated antigen 1 in marrow-derived macrophages. AGEs decreased ALP activity and showed a tendency to decrease bone nodule formation in MC3T3-E1 cells. AGEs suppressed the expression of osteoblast-specific genes, lysyl hydroxylase and lysyl oxidase in MC3T3-E1 cells.
Conclusion: AGEs suppressed differentiation and function of osteoclasts and osteoblasts, and collagen cross-linking activity. It suggests that AGE may induce bone fragility through low bone turnover and deterioration of bone quality
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참고문헌 (31)
참고문헌 신청
Vestergaard P / 2007 / Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2diabetes--a meta-analysis / Osteoporos Int 18(4):427~444
Wang J / 2016 / Increased risk of vertebral fracture in patients with diabetes : a meta-analysis of cohort studies / Int Orthop 40(6):1299~1307
Hough FS / 2016 / Mechanisms in endocrinology : mechanisms and evaluation of bone fragility in type 1 diabetes mellitus / Eur J Endocrinol 174(4):R127~R138
Brown SJ / 2015 / Diabetic peripheral neuropathy compromises balance during daily activities / Diabetes Care 38(6):1116~1122
Vavanikunnel J / 2019 / Association between glycemic control and risk of fracture in diabetic patients : a nested case-control study / J Clin Endocrinol Metab 104(5):1645~1654
Wang J / 2016 / Increased risk of vertebral fracture in patients with diabetes : a meta-analysis of cohort studies / Int Orthop 40(6):1299~1307
Hough FS / 2016 / Mechanisms in endocrinology : mechanisms and evaluation of bone fragility in type 1 diabetes mellitus / Eur J Endocrinol 174(4):R127~R138
Brown SJ / 2015 / Diabetic peripheral neuropathy compromises balance during daily activities / Diabetes Care 38(6):1116~1122
Vavanikunnel J / 2019 / Association between glycemic control and risk of fracture in diabetic patients : a nested case-control study / J Clin Endocrinol Metab 104(5):1645~1654
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