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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.24 No.3
- 발행연도
- 2018.1
- 수록면
- 422 - 430 (9page)
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Background/Aims Diarrhea-predominant irritable bowel syndrome (IBS-D) is a prevalent functional bowel disorder. Abdominal pain, discomfort and altered intestinal habits are the salient features of IBS-D. Low grade inflammation and altered neurotransmitters are the 2 recently identified factors contributing to the pathogenesis of IBS-D, but their role and interactions has not been elucidated in detail. Here we investigate the potential role of γ-aminobutyric acid (GABA) in regulating gut inflammation during IBS-D. Methods Blood samples and colonic mucosal biopsies from clinically diagnosed IBS-D patients and controls were collected. Levels of GABA were measured in serum samples through enzyme-linked immunosorbent assay (ELISA). Expression of GABAergic system and proinflammatory cytokines were analyzed in biopsy samples by reverse transcriptase polymerase chain reaction (RT-PCR). Effect of GABA and its antagonist on the expression of proinflammatory cytokines in lipopolysaccharide (LPS)-stimulated HT-29 cells was examined through RT-PCR. Results ELISA data revealed diminished level of GABA in IBS-D patients as compared to controls. RT-PCR analysis showed altered GABAergic signal system in IBS-D patients as compared to controls. GABA reduced the expression of proinflammatory cytokines in LPS stimulated HT-29 cells, whereas bicuculline methiodide (GABA antagonist) upregulated the expression of same cytokines in LPS stimulated HT-29 cells. Conclusions Our sets of data indicate that diminished level of GABA and altered GABAergic signal system contributes to pathogenesis of IBS-D by regulating inflammatory processes. These results provide novel evidence for anti-inflammatory role of GABA in IBS-D patients by altering the expression of pro-inflammatory cytokines.
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참고문헌 (39)
참고문헌 신청
An S / 2016 / Expression of inducible nitric oxide synthase in mast cells contributes to the regulation of inflammatory cytokines in irritable bowel syndrome with diarrhea / Neurogastroenterol Motil 28:1083~1093
Hughes PA / 2013 / Sensory neuro-immune interactions differ between irritable bowel syndrome subtypes / Gut 62:1456~1465
Govind K Makharia / 2011 / Prevalence of Irritable Bowel Syndrome: A Community Based Study From Northern India / Journal of Neurogastroenterology and Motility (JNM) 17(1):82~87
Rana SV / 2012 / Proinflammatory and anti-inflammatory cytokine response in diarrhoeapredominant irritable bowel syndrome patients / Trop Gastroenterol 33:251~256
Cremon C / 2009 / Mucosal immune activation in irritable bowel syndrome: gender-dependence and association with digestive symptoms / Am J Gastroenterol 104:392~400
Hughes PA / 2013 / Sensory neuro-immune interactions differ between irritable bowel syndrome subtypes / Gut 62:1456~1465
Govind K Makharia / 2011 / Prevalence of Irritable Bowel Syndrome: A Community Based Study From Northern India / Journal of Neurogastroenterology and Motility (JNM) 17(1):82~87
Rana SV / 2012 / Proinflammatory and anti-inflammatory cytokine response in diarrhoeapredominant irritable bowel syndrome patients / Trop Gastroenterol 33:251~256
Cremon C / 2009 / Mucosal immune activation in irritable bowel syndrome: gender-dependence and association with digestive symptoms / Am J Gastroenterol 104:392~400
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