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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Keratinocytes are constantly exposed to extracellular insults, such as ultraviolet B, toxic chemicals and mechanical stress, all of which can facilitate the aging of keratinocytes via the generation of intracellular reactive oxygen species (ROS). Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that plays a critical role in protecting keratinocytes against oxidants and xenobiotics by binding to the antioxidant response element (ARE), a cis-acting element existing in the promoter of most phase II cytoprotective genes. In the present study, we have attempted to find novel ethanol extract(s) of indigenous plants of Jeju island, Korea that can activate the Nrf2/ARE-dependent gene expression in human keratinocyte HaCaT cells. As a result, we identified that ethanol extract of Cirsium japonicum var. ussuriense Kitamura (ECJUK) elicited strong stimulatory effect on the ARE-dependent gene expression. Supporting this observation, we found that ECJUK induced the expression of Nrf2, hemoxygenase-1, and NAD(P)H:quinone oxidoreductase-1 and this event was correlated with Akt1 phosphorylation. We also found that ECJUK increased the intracellular reduced glutathione level and suppressed 12-O-tetradecanoylphorbol acetate-induced 8-hydroxyguanosine formation without affecting the overall viability. Collectively, our results provide evidence that ECJUK can protect against oxidative stress-mediated damages through the activation of Nrf2/ARE-dependent phase II cytoprotective gene expression.
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참고문헌 (15)
참고문헌 신청
Circu ML / 2010 / Reactive oxygen species, cellular redox systems, and apoptosis / Free Radic Biol Med 48:749~762
Surh YJ / 2008 / Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals / Planta Med 74:1526~1539
Kohen R / 2002 / Oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification / Toxicol Pathol 30:620~650
Kensler TW / 2007 / Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway / Annu Rev Pharmacol Toxicol 47:89~116
Sykiotis GP / 2010 / Stress-activated cap'n'collar transcription factors in aging and human disease / Sci Signal 3:re3
Surh YJ / 2008 / Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals / Planta Med 74:1526~1539
Kohen R / 2002 / Oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification / Toxicol Pathol 30:620~650
Kensler TW / 2007 / Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway / Annu Rev Pharmacol Toxicol 47:89~116
Sykiotis GP / 2010 / Stress-activated cap'n'collar transcription factors in aging and human disease / Sci Signal 3:re3
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