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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제52권 제1호
- 발행연도
- 2022.1
- 수록면
- 95 - 107 (13page)
- DOI
- 10.1007/s40005-021-00547-7
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초록· 키워드
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Purpose Low efficacy of parenteral administration of naked therapeutic genes is associated with the presence of biological barriers including circulatory monocytes that clear and eliminate foreign materials via reticuloendothelial system. Chemically synthesized inorganic strontium nanoparticles (SNPs) present a way to improve the delivery of genetic content to the targeted tissues of mammary carcinoma while protecting the load from premature degradation.
Methods Biodistribution profiles in the brain, liver, spleen, kidneys, lung, and mammary tumor of BALB/c mice were investigated at 1, 2 and 4 h following intravenous administration of fluorescent siRNA-loaded SNPs. Following SNPs-mediated in vivo delivery of p53 gene and MAPK siRNA, the effects of exogenous p53 expression and silencing of endogenous MAPK were analyzed via tumor size measurement over 14 days.
Results SNPs mainly accumulate in the liver and kidney with notable deposition in the brain, lung, spleen, and tumor tissues.
However, higher salt concentrations hindered the optimal localization of SNPs in tumor tissues. Despite lower residual accumulation in tumor tissues, mice treated with SNPs carrying either p53 gene or MAPK siRNA demonstrated slower tumor growth than those treated with the naked gene or siRNA. Unlike p53 gene, higher siRNA concentration resulted in lower regression activity of the carcinoma tissues, which might be due to unexpected off-target effects.
Conclusion The effective role of SNPs in overcoming biological barriers in vivo and supporting gene trafficking for substantial nucleic acid activities at the targeted tissues provides an opportunity for future novel therapeutic strategies for breast cancer.
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