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논문 기본 정보

자료유형
학술저널
저자정보
Seung-Kee Min (Department of Surgery Seoul National University College of Medicine Seoul Korea) Ji-Sun Kim (Bayer Korea Seoul Korea) Jang Yong Kim (Division of Vascular and Transplant Surgery Department of Surgery The Catholic University of Korea) Ui Jun Park (Division of Transplantation and Vascular Surgery Department of Surgery Keimyung University Dongsan) Taehoon Lee (Department of Internal Medicine Ulsan University Hospital University of Ulsan College of Medicine U) Jin Mo Kang (Department of Surgery Gil Medical Center Gachon University College of Medicine Incheon Korea) Sun Cheol Park (Department of Surgery College of Medicine The Catholic University of Korea Seoul Korea) Won-Il Choi (Department of Internal Medicine Myongji Hospital Goyang Korea) Ki-Hyuk Park (Division of Vascular and Endovascular Surgery Department of Surgery Daegu Catholic University Schoo) Martin Gebel (Bayer AG Wuppertal Germany)
저널정보
대한혈관외과학회 Vascular Specialist International Vascular Specialist International Vol.38 No.4
발행연도
2022.12
수록면
33 - 33 (1page)
DOI
10.5758/vsi.220039

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Purpose: This study aimed to compare the characteristics of venous thromboembolic disease (VTE) in Korean to Caucasian population. Materials and Methods: XALIA-LEA and XALIA were phase IV non-interventional prospective studies with identical designs that investigated the effect of rivaroxaban versus standard anticoagulation for VTE. Koreans accounted for the largest proportion of the overall enrolled population of XALIA-LEA. However, in the XALIA study, most patients were Caucasian. Therefore, Korean data from XALIA-LEA and Caucasian data from XALIA were used in this study. This study compared the clinical characteristics and primary outcomes of the XALIA program, including major bleeding, recurrent VTE, and all-cause mortality. Results: The Korean population was older, was less obese, and had more active cancer at baseline than the Caucasian population. Provoked VTE was more common in the Korean population. Interestingly, Koreans showed less accompanying thrombophilia than Caucasians, and factor V Leiden mutations were not detected. Korean analyses comparing the effects of rivaroxaban and standard anticoagulation with primary outcomes showed a lower incidence of major bleeding, recurrent VTE, and all-cause mortality with rivaroxaban. Similar results were obtained in the propensity score matching analysis. Conclusion: Characteristic differences were found between Korean and Caucasian VTE patients. Despite these ethnic differences, the effectiveness and safety of rivaroxaban therapy in these patients were consistent.

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