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논문 기본 정보

자료유형
학술저널
저자정보
Hwang Wonjae (Department of Rehabilitation Medicine Seoul National University College of Medicine Seoul Korea.Dep) Choi Joong Kyung (Department of Rehabilitation Medicine Seoul National University College of Medicine Seoul Korea.) Bang Moon Suk (Department of Rehabilitation Medicine Seoul National University College of Medicine Seoul Korea.Dep) Park Woong-Yang (Samsung Genome Institute Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Ko) Oh Byung-Mo (Department of Rehabilitation Medicine Seoul National University College of Medicine Seoul Korea.Dep)
저널정보
대한뇌신경재활학회 뇌신경재활 뇌신경재활 제15권 제3호
발행연도
2022.11
수록면
1 - 14 (14page)
DOI
10.12786/bn.2022.15.e27

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초록· 키워드

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Repetitive transcranial magnetic stimulation (rTMS) is gaining popularity as a research tool in neuroscience; however, little is known about its molecular mechanisms of action. The present study aimed to investigate the rTMS-induced transcriptomic changes; we performed microarray messenger RNA, micro RNA, and integrated analyses to explore these molecular events. Eight adult male Sprague-Dawley rats were subjected to a single session of unilateral rTMS at 1 Hz (n = 4) or sham (n = 4). The left hemisphere was stimulated for 20 minutes. To evaluate the cumulative effect of rTMS, eight additional rats were assigned to the 1-Hz (n = 4) or sham (n = 4) rTMS groups. The left hemisphere was stimulated for 5 consecutive days using the same protocol. Microarray analysis revealed differentially expressed genes in the rat cortex after rTMS treatment. The overrepresented gene ontology categories included the positive regulation of axon extension, axonogenesis, intracellular transport, and synaptic plasticity after repeated sessions of rTMS. A single session of rTMS primarily induced changes in the early genes, and several miRNAs were significantly related to the mRNAs. Future studies are required to validate the functional significance of selected genes and refine the therapeutic use of rTMS.

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