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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제22권 제3호
- 발행연도
- 2018.5
- 수록면
- 225 - 234 (10page)
- DOI
- https://doi.org/10.4196/kjpp.2018.22.3.225
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초록· 키워드
오류제보하기
Adenosine is a naturally occurring breakdown product of adenosine triphosphate and plays an important role in different physiological and pathological conditions. Adenosine also serves as an important trigger in ischemic and remote preconditioning and its release may impart cardioprotection. Exogenous administration of adenosine in the form of adenosine preconditioning may also protect heart from ischemia-reperfusion injury. Endogenous release of adenosine during ischemic/remote preconditioning or exogenous adenosine during pharmacological preconditioning activates adenosine receptors to activate plethora of mechanisms, which either independently or in association with one another may confer cardioprotection during ischemia-reperfusion injury. These mechanisms include activation of KATP channels, an increase in the levels of antioxidant enzymes, functional interaction with opioid receptors; increase in nitric oxide production; decrease in inflammation; activation of transient receptor potential vanilloid (TRPV) channels; activation of kinases such as protein kinase B (Akt), protein kinase C, tyrosine kinase, mitogen activated protein (MAP) kinases such as ERK 1/2, p38 MAP kinases and MAP kinase kinase (MEK 1) MMP. The present review discusses the role and mechanisms involved in adenosine preconditioning-induced cardioprotection.
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참고문헌 (67)
참고문헌 신청
Sheth S / 2014 / Adenosine receptors: expression, function and regulation / Int J Mol Sci 15:2024~2052
Mustafa SJ / 2009 / Adenosine receptors and the heart: role in regulation of coronary blood flow and cardiac electrophysiology / Handb Exp Pharmacol 193:161~188
Layland J / 2014 / Adenosine: physiology, pharmacology, and clinical applications / JACC Cardiovasc Interv 7:581~591
Liang BT / 1999 / Adenosine and ischemic preconditioning / Curr Pharm Des 5:1029~1041
Headrick JP / 2013 / Cardiovascular adenosine receptors: expression, actions and interactions / Pharmacol Ther 140:92~111
Mustafa SJ / 2009 / Adenosine receptors and the heart: role in regulation of coronary blood flow and cardiac electrophysiology / Handb Exp Pharmacol 193:161~188
Layland J / 2014 / Adenosine: physiology, pharmacology, and clinical applications / JACC Cardiovasc Interv 7:581~591
Liang BT / 1999 / Adenosine and ischemic preconditioning / Curr Pharm Des 5:1029~1041
Headrick JP / 2013 / Cardiovascular adenosine receptors: expression, actions and interactions / Pharmacol Ther 140:92~111
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