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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
한국식품영양과학회 Journal of Food Science and Nutrition Journal of Food Science and Nutrition Vol.4 No.1
발행연도
1999.3
수록면
33 - 37 (5page)

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The antimutagenic effects of buchu kimchi and Chinese cabbage kimchi and their cytotoxic effects against human cancer cell line were investigated in the Salmonella typhimurium system and MTT assay, respectively. Leek and Chinese cabbage were also evaluated in the same system. Buchu kimchi was fermented at 15℃ for 0, 6 and 9 days and Chinese cabbage kimchi was fermented at 15℃ for 4 days. Buchu kimchi samples showed somewhat higher antimutagenic effects against aflatoxin B₁ (AFB₁) than Chinese cabbage kimchi in Salmonella typhimurium TA100 strain. There was no difference on the antimutagenic activity according to the length of fermentation. Leek exerted stronger antimutagenicity against AFB₁ than Chinese cabbage in the Ames assay. In MTT assay, 6-day fermented buchu kimchi revealed the highest cytotoxicity against AGS human gastric adenocarcinoma cells in which 62% and 82% of the inhibition were observed with the addition of 100 ㎍, 400 ㎍/well, respectively. Buchu kimchi samples caused 60-70% inhibition on the proliferation of HT-29 human colon adenocarcinoma cells even at 100 ㎍/well while Chinese cabbage kimchi exhibited 60% inhibition against HT-29 at 400 ㎍/well. Leek exhibited higher antiproliferative effect against both AGS cells and HT-29 cells than Chinese cabbage in MTT assay. From these results, it is considered that buchu kimchi has stronger antimutagenic and in vitro anticancer effects than Chinese cabbage kimchi and the high inhibition rate of buchu kimchi probably results from leek, the major ingredient of buchu kimchi.

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Abstract

INTRODUCTION

MATERIALS AND METHODS

RESULTS AND DISCUSSION

ACKNOWLEDGEMENTS

REFERENCES

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