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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.12
- 수록면
- 407 - 413 (7page)
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초록· 키워드
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Heterotrimeric GTP binding proteins (G proteins) transduce signals of a variety of hormones and neurotransmitters. Go is one of the most abundant G proteins in the brain and classified as the Gi/Go family due to their sequence homology to Gi proteins. While the Gi proteins inhibit adenylyl cyclase and decrease the intracellular cAMP concentration, the functions of Go is not clearly understood despite their sequence homology to Gi. The promeylocytic leukemia zinc finger protein (PLZF) is a DNA binding transcription factor and is expressed highly in central nervous system (CNS). Several studies reported that PLZF may be involved in regulation segmentation/differentiation during CNS development. Here, I report that the alpha subunit of Go (Goα) interacts with PLZF. The interaction between Goα and PLZF was verified by using GST pulldown assay and co-immunoprecipitation. Our findings indicate that Goα could modulate gene expression via interaction with PLZF during neuronal or brain development.
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재료 및 방법
결과
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감사의 글
REFERENCES
참고문헌 (30)
참고문헌 신청
[학술지(정기간행물)] - Cell / 1992 / Receptor-to-effector signaling through G proteins Roles for beta gamma dimers as well as alpha subunits : 1069 ~ 1072
[학술지(정기간행물)] - Chen Z / 1993 / Fusion between a novel Kruppel-like zincfinger gene and the retinoic acid receptor-alpha locus due toa variant t translocation associated with acute promyelocyticleukaemia : 1161 ~ 1167
[학술지(정기간행물)] - Cook M, Gould A, Brand N, / 1995 / Expression of the zinc-finger gene PLZF at rhombomere boundaries in the vertebrate hindbrain. 92 : 2249 ~ 2253
[학술지(정기간행물)] - Doherty P / 1991 / Morphoregulatoryactivities of NCAM and N-cadherin can be accounted for byG protein-dependent activation of L- and N-type neuronalCa2+ channels : 21 ~ 33
[학술지(정기간행물)] - Ghil SH, / 2000 / Neurite outgrowth inducedby cyclic AMP can be modulated by the alpha subunit ofGo 74 : 151 ~ 158
[학술지(정기간행물)] - Chen Z / 1993 / Fusion between a novel Kruppel-like zincfinger gene and the retinoic acid receptor-alpha locus due toa variant t translocation associated with acute promyelocyticleukaemia : 1161 ~ 1167
[학술지(정기간행물)] - Cook M, Gould A, Brand N, / 1995 / Expression of the zinc-finger gene PLZF at rhombomere boundaries in the vertebrate hindbrain. 92 : 2249 ~ 2253
[학술지(정기간행물)] - Doherty P / 1991 / Morphoregulatoryactivities of NCAM and N-cadherin can be accounted for byG protein-dependent activation of L- and N-type neuronalCa2+ channels : 21 ~ 33
[학술지(정기간행물)] - Ghil SH, / 2000 / Neurite outgrowth inducedby cyclic AMP can be modulated by the alpha subunit ofGo 74 : 151 ~ 158
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Mining Proteins Associated with Oral Squamous Cell Carcinoma in Complex Networks
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Modulation of Rit Activation by the Alpha Subunit of Go
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Association between Cerebrospinal Fluid S100B Protein and Neuronal Damage in Patients with Central Nervous System Infections
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DNA and Protein Array
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Activated Protein C Anticoagulant System Dysfunction and Thrombophilia in Asia
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UCI(KEPA) : I410-ECN-0101-2009-510-017342183