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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
한국체육과학회 한국체육과학회지 한국체육과학회지 제15권 제4호
발행연도
2006.11
수록면
527 - 541 (15page)

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The purpose of this study was to investigate the caspase-3, Bcl-2, Bax mRNA and DNA fragmentation, for exercise and the artificial muscle injury induced the muscle injury. The mice(ICR) were housed two per cage in a temperature of 23~24℃ and controlled in an evironment with a cycle of 12:12h light-dark and provided with food and water. The exercise were canied out on an adapted treadmill in order for 2 animals to run at the same time. A total exercise time was 60min with the average speed of 24-25m/min. One section of Quadriceps muscle of the exercise group killed with cervical decapitation after physical activity for 1hour was cut from the RㆍL low limbs, frozen in liquid nitrogen and stored at -80℃ for analysis. The caspase-S, BcI-2, Bax transcript contents were estimated by RT-PCR DNA laddering was used to detect DNA fragmentation as an indicator of apoptosis. The results of the study can be summerized as follows ; First. caspase- 3 mRNA was significantly increased on rest, immediately after exercise and recovery at 1h, 5h, 12h after exercise in exercise group when compared with artificial muscle injury. Second, BcI-2 mRNA was significantly increased on rest, immediately after exercise and recovery at 1h, 5h, 12h after exercise in exercise group. Also, the artificial muscle injury group was increased when compared with rest, but not significantly. Third, Bax transcript was significantly increased in rest, immediately after exercise and recovery at 1h, 5h, 12h after exercise in exercise group when compared with artificial muscle injury group. And Bax mRNA of exercise group peaked at recovery 1h, The artificial muscle injury group was also increased when compared with rest, but not significantly. n rest, immediately after exercise and recovery at i1h, 5h after exercise in artificial muscle injury group when compared with the exercise group at appeared peak point on recovery 12h after the injury. In the present study, it was observed that apoptotic measurements differed in quadriceps muscle after the treatments(exhausted exercise vs artificial muscle injury). For example, it was demonstrated that exercise group commenced DNA fragmentation at 5h, increased BcI-2 and caspase-3 transcript levels, Bax m-RNA in mice quadriceps muscle had a significantly low status when compared with artificial muscle injury group.
Thus, exercise was adapted for the skeletal muscle myocite which had a programmed cell death.

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Abstract
Ⅰ. 서론
Ⅱ. 연구방법
Ⅲ. 결과
Ⅳ. 논의
Ⅴ. 결론
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UCI(KEPA) : I410-ECN-0101-2009-692-016622843