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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.20 No.1
- 발행연도
- 2015.3
- 수록면
- 73 - 77 (5page)
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초록· 키워드
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As an approach to search for chemopreventive agents, we tested p-coumaric acid, 3-methoxy-p-coumaric acid (ferulic acid), and 3,5-dimethoxy-p-coumaric acid (sinapic acid) in B16/F10 melanoma cells. Intracellular melanin contents were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay and cytotoxicity of the compounds were examined by lactate dehydrogenase (LDH) release. p-Coumaric acid showed inhibitory effect on melanogenesis, but ferulic acid increased melanin content, and sinapic acid had almost no effect on melanogenesis. Treatment with ferulic acid resulted in a 2 to 3 fold elevation in the production of melanin. Correlatively, cell viability decreased in a dose-dependent manner when treated with ferulic acid. However, ferulic acid did not affect the LDH release from the cells. Treatment with sinapic acid resulted in a 50∼60% elevation in the release of LDH when treated with a 200 μg/mL concentration and showed neither cytostasis nor increase of melanin synthesis in a dose-dependent manner. Taken together, p-coumaric acid inhibits melanogenesis, ferulic acid induces melanogenesis, and sinapic acid exerts cytotoxic effects in B16/F10 murine melanoma cells. The results indicate that the addition of methoxy groups to p-coumaric acid shows the melanogenic or cytotoxic effects in melanoma cells compared to the original compound. Therefore, this study suggests the possibility that methoxylated p-coumaric acid, ferulic acid can be used as a chemopreventive agent.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (24)
참고문헌 신청
1. [학술지(정기간행물)] - Chin L / 2006 / Malignant melanoma : Genetics and therapeutics in the genomic era / Genes Dev 20 : 2149 ~ 2182
2. [학술지(정기간행물)] - 윤훈석 / 2011 / Nobiletin Induces Differentiation of Murine B16/F10 Melanoma Cells / Applied Biological Chemistry 54 (3) : 353 ~ 361
3. [학술지(정기간행물)] - Fisher PB / 1985 / Effects of interferon on differentiation of normal and tumor cells / Pharmacol Ther 27 : 143 ~ 166
4. [학술지(정기간행물)] - Jiménez M / 1988 / Mammalian tyrosinase : Biosynthesis, processing, and modulation by melanocyte-stimulating hormone / Proc Natl Acad Sci USA 85 : 3830 ~ 3834
5. [학술지(정기간행물)] - Videria IFS / 2013 / Mechanisms regulating melanogenesis / An Bras Dermatol 88 : 76 ~ 83
2. [학술지(정기간행물)] - 윤훈석 / 2011 / Nobiletin Induces Differentiation of Murine B16/F10 Melanoma Cells / Applied Biological Chemistry 54 (3) : 353 ~ 361
3. [학술지(정기간행물)] - Fisher PB / 1985 / Effects of interferon on differentiation of normal and tumor cells / Pharmacol Ther 27 : 143 ~ 166
4. [학술지(정기간행물)] - Jiménez M / 1988 / Mammalian tyrosinase : Biosynthesis, processing, and modulation by melanocyte-stimulating hormone / Proc Natl Acad Sci USA 85 : 3830 ~ 3834
5. [학술지(정기간행물)] - Videria IFS / 2013 / Mechanisms regulating melanogenesis / An Bras Dermatol 88 : 76 ~ 83
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UCI(KEPA) : I410-ECN-0101-2016-594-001353460