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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.12
- 수록면
- 283 - 288 (6page)
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In this study, we investigated anti-obesity effect of isoegomaketone (IK) isolated from leaves extract of Perilla frutescens (L.) Britt. cv. We verified differentiation and lipid accumulation by Oil Red O staining in 3T3-L1 cells after IK treatment with differentiation media. IK inhibited mRNA expression of adipocyte specific genes that were related with differentiation of 3T3-L1 cells. We confirmed the effects of IK on body weight and visceral fat mass in obese mice. Mice were randomly divided into three groups; normal diet group (ND), high-fat diet group (HFD) and high-fat diet with IK group (HFD-IK). The obesity mice were induced by feeding the 45% high-fat diet to the C57BL/6J mice during 4 weeks. After HFD-IK was orally administered 10 mg/kg of IK. As a result, the body weight of HFD and HFD-IK was increased 2.4 times and 1.7 times of ND, respectively. Also visceral fat mass of HFD was increased 24 times but in the case of HFD-IK was increased to 13 times in comparison with ND. Taken together, our findings suggest that IK reduced differentiation and adiogenesis in 3T3-L1 cells, decreased the body weight and visceral fat mass in obesity mice. These results suggest that IK may have a potential benefit as anti-obesity material.
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참고문헌 (19)
참고문헌 신청
McGee, D. L. / 2005 / Body mass index and mortality:A metaanalysis based on person-leveldata from twenty-six observational studies / Ann. Epidemiol 15:377~398
Peter, G. K / 2000 / Obesity as a medical problem / Nature 404:635~643
Lementowski, P. W / 2008 / Obesity and osteoarthritis / Am. J. Orthop 37:148~151
Yiying, Z. / 1994 / Positional cloning of the mouse obese gene and its human homologue / Nature 372:425~432
Johansson, K. / 2009 / Discontinuation due to adverse events in randomized trials of orlistat, sibutramine and rimonabant: a meta-analysis / Obes. Rev 10:564~575
Peter, G. K / 2000 / Obesity as a medical problem / Nature 404:635~643
Lementowski, P. W / 2008 / Obesity and osteoarthritis / Am. J. Orthop 37:148~151
Yiying, Z. / 1994 / Positional cloning of the mouse obese gene and its human homologue / Nature 372:425~432
Johansson, K. / 2009 / Discontinuation due to adverse events in randomized trials of orlistat, sibutramine and rimonabant: a meta-analysis / Obes. Rev 10:564~575
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