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논문 기본 정보

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학술저널
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대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제16권 제4호
발행연도
2018.1
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469 - 480 (12page)

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Objective: Pharmacogenomic-based antidepressant treatment (PGATx) may result in more precise pharmacotherapy of major depressive disorder (MDD) with better drug therapy guidance. Methods: An 8-week, randomized, single-blind clinical trial was conducted to evaluate the effectiveness and tolerability of PGATx in 100 patients with MDD. All recruited patients were randomly allocated either to PGATx (n=52) or treatment as usual (TAU, n=48) groups. The primary endpoint was a change of total score of the Hamilton Depression Rating Scale-17 (HAMD-17) from baseline to end of treatment. Response rate (at least 50% reduction in HAMD-17 score from baseline), remission rate (HAMD-17 score ≤7 at the end of treatment) as well as the change of total score of Frequency, Intensity, and Burden of Side Effects Ratings (FIBSER) from baseline to end of treatment were also investigated. Results: The mean change of HAMD-17 score was significantly different between two groups favoring PGATx by −4.1 point of difference (p=0.010) at the end of treatment. The mean change in the FIBSER score from baseline was significantly different between two treatment groups favoring PGATx by −2.5 point of difference (p=0.028). The response rate (71.7 % vs. 43.6%, p=0.014) were also significantly higher in PGATx than in TAU at the end of treatment, while the remission rate was numerically higher in PGATx than in TAU groups without statistical difference (45.5% vs. 25.6%, p=0.071). The reason for early drop-out associated with adverse events was also numerically higher in TAU (n=9, 50.0%) than in PGATx (n=4, 30.8%). Conclusion: The present study clearly demonstrate that PGATx may be a better treatment option in the treatment of MDD in terms of effectiveness and tolerability; however, study shortcomings may limit a generalization. Adequately-powered, well-designed, subsequent studies should be mandatory to prove its practicability and clinical utility for routine practice.

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참고문헌 (7)

참고문헌 신청
David M. Marks / 2008 / Triple Reuptake Inhibitors: A Premise and Promise / PSYCHIATRY INVESTIGATION 5(3):142~147 dbpia 왕희령 / 2017 / Korean Medication Algorithm for Depressive Disorder: Comparisons with Other Treatment Guidelines / Clinical Psychopharmacology and Neuroscience 15(3):199~209 dbpia Ajeet B. Singh / 2015 / Improved Antidepressant Remission in Major Depression via a Pharmacokinetic Pathway Polygene Pharmacogenetic Report / Clinical Psychopharmacology and Neuroscience 13(2):150~156 dbpia Patkar AA / 2013 / Atypical antipsychotic augmentation strategies in the context of guideline-based care for the treatment of major depressive disorder / CNS Drugs 27(Suppl 1):S29~S37 google schola Pae CU / 2013 / Clinical issues in use of atypical antipsychotics for depressed patients / CNS Drugs 27(Suppl 1):S39~S45 google schola

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