지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Major depressive disorder (MDD) is a recurrent, chronic, and devastating disorder leadingto serious impairment in functional capacity as well as increasing public healthcare costs. In the previous decade, switching therapy and dose adjustment of ongoingantidepressants was the most frequently chosen subsequent treatment option forMDD. However, such recommendations were not based on firmly proven efficacy datafrom well-designed, placebo-controlled, randomized clinical trials (RCTs) but on practicalgrounds and clinical reasoning. Aripiprazole augmentation has been dramaticallyincreasing in clinical practice owing to its unique action mechanisms as well as provenefficacy and safety from adequately powered and well-controlled RCTs. Despite the increaseduse of aripiprazole in depression, limited clinical information and knowledgeinterfere with proper and efficient use of aripiprazole augmentation for MDD. The objectiveof the present review was to enhance clinicians’ current understanding of aripiprazoleaugmentation and how to optimize the use of this therapy in the treatment ofMDD.
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참고문헌 (122)
참고문헌 신청
Kessler RC. / 2003 / The epidemiology of major depressive disorder : results from the National Comorbidity Survey Replication(NCS-R) / JAMA 289:3095~3105
Kessler RC. / 2013 / The epidemiology of depression across cultures / Annu Rev Public Health 34:119~138
Fava M. / 2003 / Background and rationale for the sequenced treatment alternatives to relieve depression(STAR*D)study / Psychiatr Clin North Am 26:457~494
Trivedi MH. / 2006 / Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D : implications for clinical practice / Am J Psychiatry 163:28~40
Wang SM. / 2015 / Criticisms of drugs in early development for the treatment of depression : what can be improved? / Expert Opin Investig Drugs 24:445~453
Kessler RC. / 2013 / The epidemiology of depression across cultures / Annu Rev Public Health 34:119~138
Fava M. / 2003 / Background and rationale for the sequenced treatment alternatives to relieve depression(STAR*D)study / Psychiatr Clin North Am 26:457~494
Trivedi MH. / 2006 / Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D : implications for clinical practice / Am J Psychiatry 163:28~40
Wang SM. / 2015 / Criticisms of drugs in early development for the treatment of depression : what can be improved? / Expert Opin Investig Drugs 24:445~453
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