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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 89 - 98 (10page)
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A synthesis method for a chitosan-coated magnetic drug-delivery system of cisplatin is proposed. Here, cisplatin was conjugated to the surface of Magnetite (Fe3O4) nanoparticles via a (3-Aminopropyl)-trimethoxysilane (APTS) coupling agent. To reduce the cytotoxic effect of cisplatin, the magnetic drug was then encapsulated in chitosan (CS-cisplatin-Fe3O4) through the water/oil (W/O) emulsion method. The CS-cisplatin-Fe3O4 nanoparticles were synthesized in a spherical shape with a diameter of 190 nm. The cytotoxicity assay was performed using HeLa cells. The cisplatin uptake of the cells was determined using High Performance Liquid Chromatography (HPLC) to calculate the drug content. The controlled release of cisplatin was demonstrated by regulating the dissolution and diffusion of the drug through the chitosan matrix.
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참고문헌 (25)
참고문헌 신청
[학술지(
Arum Y / 2011 / Controlling the optimum dose of AMPTS functionalized-magnetite nanoparticles for hyperthermia cancer therapy / Appl Nanosci 1 : 237 ~ 246
Bae KH / 2012 / Chitosan oligosaccharide-stabilized ferrimagnetic iron oxide nanocubes for magnetically modulated cancer hyperthermia / ACS nano 6 : 5266 ~ 5273
Bhattarai N / 2010 / Chitosan-based hydrogels for controlled, localized drug delivery / Adv Drug Deliv Rev 62 : 83 ~ 99
Bhowmick T / 2010 / In vitro effects of cisplatin-functionalized silica nanoparticles on chondrocytes / J Nanopart Res 12 : 2757 ~ 2770
Arum Y / 2011 / Controlling the optimum dose of AMPTS functionalized-magnetite nanoparticles for hyperthermia cancer therapy / Appl Nanosci 1 : 237 ~ 246
Bae KH / 2012 / Chitosan oligosaccharide-stabilized ferrimagnetic iron oxide nanocubes for magnetically modulated cancer hyperthermia / ACS nano 6 : 5266 ~ 5273
Bhattarai N / 2010 / Chitosan-based hydrogels for controlled, localized drug delivery / Adv Drug Deliv Rev 62 : 83 ~ 99
Bhowmick T / 2010 / In vitro effects of cisplatin-functionalized silica nanoparticles on chondrocytes / J Nanopart Res 12 : 2757 ~ 2770
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