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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 353 - 359 (7page)
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초록· 키워드
오류제보하기
Hepatitis C virus (HCV) is known as the causative agent of blood transmitted hepatitis. Two
viral proteins, E2 and NS5A, are known to exert interferon resistance of HCV via PKR pathway. Here, we report a third protein, the RNA-dependent RNA polymerase (NS5B) of HCV, induced interferon resistanceinhibiting p56 pathway. p56 was shown to interact with p48 subunit of eukaryotic initiation factor 3 (eIF3).This interaction inhibited formation of ternary complex in translation initiation. Using dual reporter assay system,we observed that the translation decreased when interferon alpha was added to the culture. But, in the presence of HCV NS5B, the translation partly recovered. NS5B and p48 subunit of eIF3 were shown to interact. This interaction seems to inhibit the interaction between p48 and p56. This is the first report that a virus exerts interferon resistance via p56 pathway.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Al, R. H. / 1998 / Expression of recombinant hepatitis C virus non-structural protein 5B in Escherichia coli / Virus Res 53 : 141 ~ 149
Ali, N. / 1995 / Interaction of polypyrimidine binding protein with the 5' noncoding region of the HCV RNA genome and its functional requirement in internal initiation of tra
Ali, N. / 1997 / Interaction of polypyrimidine tract binding protein with the 5' noncoding region of the hepatitis C virus RNA genome and its functional requirement in intern
Bartenschlager, R. / 1994 / Kinetic and structural analyses of hepatitis C virus polyprotein processing / J. Virol 68 : 5045 ~ 5055
Bartenschlager, R. / 1999 / Replication of subgenomic Hepatitis C virus RNAs in a Hepatoma cell line / Science : 110 ~ 113
Ali, N. / 1995 / Interaction of polypyrimidine binding protein with the 5' noncoding region of the HCV RNA genome and its functional requirement in internal initiation of tra
Ali, N. / 1997 / Interaction of polypyrimidine tract binding protein with the 5' noncoding region of the hepatitis C virus RNA genome and its functional requirement in intern
Bartenschlager, R. / 1994 / Kinetic and structural analyses of hepatitis C virus polyprotein processing / J. Virol 68 : 5045 ~ 5055
Bartenschlager, R. / 1999 / Replication of subgenomic Hepatitis C virus RNAs in a Hepatoma cell line / Science : 110 ~ 113
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