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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 425 - 442 (18page)
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Objectives: This study aimed to reveal the pharmacological properties of the newly prescribed herbal mixture, Chenmadansam- gamibokhap-tang (CDBT), against hypoxia-induced neuronal cell injury (especially mouse hippocampal neuronal cell line, HT-22 cells) and their corresponding mechanisms. Methods: A cell-based in vitro experiment, in which a hypoxia condition induced neuronal cell death, was performed. Various concentrations of the CDBT were pre-treated to the HT-22 cells for 4 h before 18 h in the hypoxia chamber. The glial cell BV-2 cells were stimulated with IFNγ and LSP to produce inflammatory cytokines and reactive oxygen species. When the neuronal HT-22 cells were treated with this culture solution, the drug efficacy against neuronal cell death was examined. Results: CDBT showed cytotoxicity in the normal condition of HT-22 cells at a dose of 125 μg/mL and showed a protective effect against hypoxia-induced neuronal cell death at a dose of 31.3 μg/mL. CDBT prevented hypoxia-induced neuronal cell death in a dose-dependent manner in the HT-22 cells by regulating HIF1α and cell death signaling. CDBT prevented neuronal cell death signals and DNA fragmentation due to the hypoxia condition. CDBT significantly reduced cellular oxidation, cell death signals, and caspase-3 activities due to microglial cell activations. Moreover, CDBT significantly ameliorated LPS-induced BV-2 cell activation and evoked cellular oxidation through the recovery of redox homeostasis. Conclusions: CDBT cam be considered as a vital therapeutic agent against neuronal cell deaths. Further studies are required to reveal the other functions of CDBT in vivo or in the clinical field.
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참고문헌 (45)
참고문헌 신청
Winek K / 2016 / Depletion of Cultivatable Gut Microbiota by Broad-Spectrum Antibiotic Pretreatment Worsens Outcome After Murine Stroke / Stroke 47(5):1354~1363
Donnan GA / 2008 / Stroke / Lancet 371(9624):1612~1623
Paraskevas KI / 2008 / Secondary prevention of stroke / Lancet 372(9643):1036
Lee JC / 2006 / Aging and Stroke / Kor J Gerontol 16:11~16
Li P / 2017 / An Antagomir to MicroRNA-106b-5p Ameliorates Cerebral Ischemia and Reperfusion Injury in Rats Via Inhibiting Apoptosis and Oxidative Stress / Mol Neurobiol 54(4):2901~2921
Donnan GA / 2008 / Stroke / Lancet 371(9624):1612~1623
Paraskevas KI / 2008 / Secondary prevention of stroke / Lancet 372(9643):1036
Lee JC / 2006 / Aging and Stroke / Kor J Gerontol 16:11~16
Li P / 2017 / An Antagomir to MicroRNA-106b-5p Ameliorates Cerebral Ischemia and Reperfusion Injury in Rats Via Inhibiting Apoptosis and Oxidative Stress / Mol Neurobiol 54(4):2901~2921
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