지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 197 - 205 (9page)
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초록· 키워드
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Background: Early-onset and severe atopic dermatitis (AD) in patients increase the probability of the development of allergic rhinitis or asthma. Treatment and prevention strategies in infants and young children with AD are targeted toward treating the symptoms, restoring skin barrier functions, and reducing the absorption of environmental allergens in an attempt to attenuate or block the onset of asthma and food allergy. Objective: Given that the initiating events in AD remain poorly understood, identifying those at risk and implementing strategies to prevent AD is necessary. Methods: Whole-exome sequencing (WES) was performed in a 43 control group and a disease group with 20 AD patients without atopic march (AM) and 20 with AM. Sanger sequencing was carried out to validate found variants in cohorts. Results: DOCK8, IL17RA, and KLK12 single-nucleotide polymorphisms were identified by WES as missense mutations: c.1289C＞ A, p.P97T (rs529208); c.1685C＞A, p.P562G (rs12484684); and c.457+27＞C, rs3745540, respectively. A case-control study show that total immunoglobulin E (IgE) level was significantly increased in the AA genotype of DOCK8 compared to the CA genotype in allergic patients. The rs12484684 of IL17RA increased risk of adult-onset AD (odds ratio: 1.63) compared to the control for (A) allele frequency. AD and AM Patients with the IL17RA CA genotype also had elevated IgE levels. rs3745540 of KLK12 was associated with AD in dominant model (odds ratio: 2.86). Conclusion: DOCK8 (rs529208), IL17RA (rs12484684), and KLK12 (rs3745540), were identified using a new WES filtering method. the result suggests that polymorphism of DOCK8 and IL17RA might be related to increase the total IgE level.
목차
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참고문헌 (27)
참고문헌 신청
Bantz SK / 2014 / The atopic march : progression from atopic dermatitis to allergic rhinitis and asthma / J Clin Cell Immunol 5:202
Thomsen SF / 2014 / Atopic dermatitis: natural history, diagnosis, and treatment / ISRN Allergy 2014:354250
Peng W / 2014 / Recent developments in atopic dermatitis / Curr Opin Allergy Clin Immunol 14:417~422
편복양 / 2015 / Natural History and Risk Factors of Atopic Dermatitis in Children / Allergy, Asthma & Immunology Research 7(2):101~105
Zaniboni MC / 2016 / Skin barrier in atopic dermatitis : beyond filaggrin / An Bras Dermatol 91:472~478
Thomsen SF / 2014 / Atopic dermatitis: natural history, diagnosis, and treatment / ISRN Allergy 2014:354250
Peng W / 2014 / Recent developments in atopic dermatitis / Curr Opin Allergy Clin Immunol 14:417~422
편복양 / 2015 / Natural History and Risk Factors of Atopic Dermatitis in Children / Allergy, Asthma & Immunology Research 7(2):101~105
Zaniboni MC / 2016 / Skin barrier in atopic dermatitis : beyond filaggrin / An Bras Dermatol 91:472~478
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