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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 891 - 894 (4page)
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The cellular entry of severe respiratory syndrome coronavirus-2 (SARS-CoV-2) is mediated by interaction with the human angiotensin-converting enzyme 2 (ACE2), a receptor that is expressed on both lung and intestinal epithelial cells. We performed a quantitative proteomic analysis to investigate the expression of possible receptors for SARS-CoV-2 in the intestinal mucosa of 23 patients with chronic colitis. ACE2 expression was low and remained unaltered in the gut of patients with ulcerative colitis (UC), Crohn’s disease (CD), intestinal Beh?et’s disease (BD), and intestinal tuberculosis (TB), when compared with that of healthy individuals. Additionally, the expression levels of some probable co-receptors, including dipeptidyl peptidase 4 (DPP4), aminopeptidase N (AMPN), and glutamyl aminopeptidase (AMPE), were unchanged in the affected UC, CD, intestinal BD, and intestinal TB colon mucosa samples. In conclusion, gut inflammation associated with chronic colitis does not mediate a further increase in the cellular entry of SARS-CoV-2.
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참고문헌 (12)
참고문헌 신청
Guan WJ / 2020 / Clinical characteristics of coronavirus disease 2019 in China / N Engl J Med 382:1708~1720
Hoffmann M / 2020 / SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor / Cell 181:271~280
Harmer D / 2002 / Quantitative mRNA expression profiling of ACE 2, a novel homologue of angiotensin converting enzyme / FEBS Lett 532:107~110
Goyal P / 2020 / Clinical characteristics of COVID-19 in New York City / N Engl J Med 382:2372~2374
Xiao F / 2020 / Evidence for gastrointestinal infection of SARS-CoV-2 / Gastroenterology 158:1831~1833
Hoffmann M / 2020 / SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor / Cell 181:271~280
Harmer D / 2002 / Quantitative mRNA expression profiling of ACE 2, a novel homologue of angiotensin converting enzyme / FEBS Lett 532:107~110
Goyal P / 2020 / Clinical characteristics of COVID-19 in New York City / N Engl J Med 382:2372~2374
Xiao F / 2020 / Evidence for gastrointestinal infection of SARS-CoV-2 / Gastroenterology 158:1831~1833
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