메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
Tadayuki Oshima (Division of Gastroenterology Department of Internal Medicine Hyogo College of Medicine Nishinomiya) Hiroto Miwa (Division of Gastroenterology Department of Internal Medicine Hyogo College of Medicine Japan)
저널정보
대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.24 No.3
발행연도
2018.1
수록면
334 - 344 (11page)

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
Conventional proton pump inhibitors (PPIs) are used as a first-line therapy to treat acid-related diseases worldwide. However, theyhave a number of limitations including slow onset of action, influence by cytochrome P450 polymorphisms, unsatisfactory effectsat night, and instability in acidic conditions. Alternative formulations of conventional PPIs have been developed to overcome theseproblems; however, these drugs have only introduced small advantages for controlling acid secretion compared to conventional PPIs. Potassium-competitive acid blockers (P-CABs) were developed and have beneficial effects including rapid, long-lasting, and reversibleinhibition of the gastric hydrogen potassium ATPase, the proton pump of the stomach. Vonoprazan was recently innovated as a novel,orally active P-CAB. It is currently indicated for the treatment of gastric and duodenal ulcers, reflux esophagitis, and prevention of lowdoseaspirin- or nonsteroidal anti-inflammatory drug-related gastric and duodenal ulcer recurrence in Japan. Vonoprazan does notrequire enteric coating as it is acid-stable, and it can be taken without food because it is quickly absorbed. Vonoprazan accumulatesin parietal cells under both acidic and neutral conditions. It does not require an acidic environment for activation, has long-termstability at the site of action, and has satisfactory safety and tolerability. Thus, vonoprazan may address the unmet medical need forthe treatment of acid-related diseases.

목차

등록된 정보가 없습니다.

참고문헌 (116)

참고문헌 신청

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0